نتایج جستجو برای: mammary cancer
تعداد نتایج: 941129 فیلتر نتایج به سال:
Mammary stem/progenitor cells (MaSCs) maintain self-renewal of the mammary epithelium during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism for maintaining cellular memory during self-renewal. Although DNA methyltransferases (DNMTs) are dispensable for embryonic stem cell maintenance, their role in maintaining MaSCs and cancer stem cells (CSCs) in constantly re...
Parameters of collagen biosynthesis were determined in mammary cancer tissue. Peptidylproline hydroxylase (PPH) activity was determined in spontaneous primary mammary cancer tissue and normal mammary gland in fat pad. The enzyme was located in the 105,000 X g supernatant of whole-tissue homogenates. Ascorbate, a-ketoglutarate, and ferrous ion were required for enzyme activity of cancerous and c...
AbstractEpidermal inclusion cysts are uncommon in the breast, but the consequences can besevere when these cysts occur in the breast parenchyma. Here, we report two suchcases. The patient in case 1 was an 37-year-old woman with a 3-cm palpable mass inthe right breast. Mammography revealed a round and smoothly outlined mass, whichindicated a benign tumor, and sonography showed an irregularly sha...
The current studies demonstrate the critical importance of ovarian hormones in the initiation and promotion of carcinogenesis of mammary glands in rats by polynuclear hydrocarbons. Removal of ovarian hormones from the rats immediately after the ad ministration of the carcinogenic hydrocarbons either inhibited or profoundly reduced the incidence of mammary cancer. Excision of ovaries beyond 7 da...
Immunotherapy is currently emerging mode of breast cancer therapy as efficacy of traditional therapies seems to reach plateau nowadays. First transplanted generation from non-SPF spontaneous BLRB mammary adenocarcinoma (MAC) were used as appropriate mouse model to examine whether single local interleukin-2 (IL-2) is efficient against mammary cancer. We showed that survival dynamics of syngeneic...
The mammary gland is an organ comprising two primary lineages, specifically the inner luminal and the outer myoepithelial cell layers. Mammary gland stem cells (MaSCs) are highly dynamic and self-renewing, and can give rise to these mammary gland lineages. The lineages are responsible for gland generation during puberty as well as expansion during pregnancy. In recent years, researchers have fo...
Maternal exposures to environmental factors during pregnancy influence the risk of many chronic adult-onset diseases in the offspring. Here we investigate whether feeding pregnant rats a high-fat (HF)- or ethinyl-oestradiol (EE2)-supplemented diet affects carcinogen-induced mammary cancer risk in daughters, granddaughters and great-granddaughters. We show that mammary tumourigenesis is higher i...
Mouse mammary tumor virus (MMTV), which was discovered as a milk-transmitted, infectious cancer-inducing agent in the 1930s, has been used since that time as an animal model for the study of human breast cancer. Like other complex retroviruses, MMTV encodes a number of accessory proteins that both facilitate infection and affect host immune response. In vivo, the virus predominantly infects lym...
We analyzed the effect of molecular iodine (I2), potassium iodide (KI) and a subclinical concentration of thyroxine (T4) on the induction and promotion of mammary cancer induced by N-methyl-N-nitrosourea. Virgin Sprague-Dawley rats received short or continuous treatment. Continuous I2 treated rats exhibited a strong and persistent reduction in mammary cancer incidence (30%) compared to controls...
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