UNLABELLED : Diffusion maps are a spectral method for non-linear dimension reduction and have recently been adapted for the visualization of single-cell expression data. Here we present destiny, an efficient R implementation of the diffusion map algorithm. Our package includes a single-cell specific noise model allowing for missing and censored values. In contrast to previous implementations, w...

As is well known, it is our manifest destiny as 21st century algebraic topologists to compute homotopy groups of spheres. This noble venture began even before the notion of homotopy was around. In 1931, Hopf was thinking about a map he had encountered in geometry from S to S and wondered whether or not it was essential. He proved that it was by considering the linking of the fibers. After Hurew...

My brief article (Lynn, 2001) on hidden observers and informed consent seems to have jangled a raw nerve among a group of commentators whose names are a virtual “who’s who” of the proponents of the use of hypnosis for memory recovery and of ego-state and dissociation-based therapies and theories. Dr. Kluft is right: “Proponents of paradigms often conduct themselves as if they were the agents of...

Speaking about the destiny of Man and his future is principally mixed with an argument about the destiny and the future of culture. Human destiny is determined by the culture through which he reaches perfection within his “human” identity. Now, in our times, the issue of whether culture could secure mankind from the dangers of the exploding political situation of the world is considered very im...

To enable the design of large capacity memory structures, novel memory technologies such as non-volatile memory (NVM) and novel fabrication approaches, e.g., 3D stacking and multi-level cell (MLC) design have been explored. The existing modeling tools, however, cover only a few memory technologies, technology nodes and fabrication approaches. We present DESTINY, a tool for modeling 2D/3D memori...

This paper outlines how our highly efficient, power-aware supercomputer called Green Destiny and our open-source parallelization of BLAST called mpiBLAST combine to create a bit of “bioinfomagic.” Green Destiny, featured in The New York Times and winner of a 2003 R&D 100 Award, revolutionized high-performance computing by re-defining performance to focus on issues of efficiency, reliability, an...

Differentiation to Ab secreting and isotype-switched effector cells is tightly linked to cell division and therefore the degree of proliferation strongly influences the nature of the immune response. The maximum number of divisions reached, termed the population division destiny, is stochastically distributed in the population and is an important parameter in the quantitative outcome of lymphoc...