Microtubule Affinity-Regulating Kinase 2 (MARK2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. The abnormal function of this protein has been associated with a number of pathological conditions like Alzheimer disease, autism, several carcinomas and development of...

MARK4, also known as Par-1d/ MarkL1, is a member of the AMPK-related family of kinases which are implicated in the regulation of dynamic biological functions, including glucose and energy homeostasis. However, the physiological function of MARK4 in mammals remains elusive. Here we investigated a role of MARK4 in regulating energy homeostasis by generating mice with targeted inactivation of the ...

microtubule affinity-regulating kinase 2 (mark2) protein has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation. the abnormal function of this protein has been associated with a number of pathological conditions like alzheimer disease, autism, several carcinomas and development of...

MARK/Par-1, a kinase family with diverse functions particularly in inducing cell polarity, can phosphorylate microtubule-associated proteins in their repeat domain and cause their detachment from microtubules, and thereby microtubule destabilization. Because of its role in abnormal phosphorylation of the Tau protein in Alzheimer disease, we searched for regulatory kinases. MARK family kinases c...

Johannes Handsteiner1,∗ Andrew S. Friedman2,† Dominik Rauch1, Jason Gallicchio3, Bo Liu1,4, Hannes Hosp1, Johannes Kofler5, David Bricher1, Matthias Fink1, Calvin Leung3, Anthony Mark2, Hien T. Nguyen6, Isabella Sanders2, Fabian Steinlechner1, Rupert Ursin1,7, Sören Wengerowsky1, Alan H. Guth2, David I. Kaiser2, Thomas Scheidl1, and Anton Zeilinger1,7‡ 1Institute for Quantum Optics and Quantum ...

Epithelial differentiation involves the generation of luminal surfaces and of a noncentrosomal microtubule (MT) network aligned along the polarity axis. Columnar epithelia (e.g., kidney, intestine, and Madin-Darby canine kidney [MDCK] cells) generate apical lumina and orient MT vertically, whereas liver epithelial cells (hepatocytes and WIFB9 cells) generate lumina at cell-cell contact sites (b...