Massive pulmonary haemorrhage in the newborn is a well-recognized but little understood condition, characterized by the presence in the alveoli and alveolar ducts, and sometimes in the interstitial spaces, of large numbers of erythrocytes. The distribution of haemorrhage may be patchy or confluent causing consolidation, as distinct from the petechial haemorrhages seen in infants dying after pre...

We report the first result of a supernova search program designed to measure the evolution of the supernova rate with redshift. To make the comparison with local rates more significant we copied, as much as possible, the same computation recepies as for the measurements of local rates. Moreover, we exploited the mul-ticolor images and the photometric redshift technique to characterize the galax...

How massive stars die – what sort of explosion and remnant each produces – depends chiefly on the masses of their helium cores and hydrogen envelopes at death. For single stars, stellar winds are the only means of mass loss, and these are chiefly a function of the metallicity of the star. We discuss how metallicity, and a simplified prescription for its effect on mass loss, affects the evolutio...

background: our study aimed at substantiating the recent claim of myo-cardial complications in severe malaria by experimentally inducing severe plasmodium falciparum infection in a humanized mouse model employed as human surrogate. methods: twenty five humanized mice were inoculated with standard in vitro cultured p. falciparum and blood extracts collected from the inner cardiac muscles of infe...

UNLABELLED The adverse health effects of cigarette smoking are well established including the increased risk of various types of cancer. In this study, the direct effects of ethanol, pure nicotine, cigarette smoke extract and Swedish type smokeless tobacco (Snus) extract on normal cells were investigated. MATERIALS AND METHODS Primary normal adult human endothelial cells and fibroblasts at ea...

Several causal missense mutations in protein kinase C gamma (gamma PKC) gene have been found in spinocerebellar ataxia type 14 (SCA14), an autosomal dominant neurodegenerative disease. We previously demonstrated that mutant gamma PKC found in SCA14 is susceptible to two types of aggregation, cytoplasmic dot-like and perinuclear massive aggregation, and causes cell death in Chinese hamster ovary...

I n patients with hypertrophic cardiomyopathy (HCM), the low positive predictive accuracy of the previously recognised risk factor for sudden death—that is, non-sustained ventricular tachycardia, syncope, abnormal blood pressure response to exercise, family history of sudden death, and massive left ventricular (LV) hypertrophy—is a major limitation. Patients with a combination of two or more su...

BACKGROUND Antifibrinolytic agents are commonly used during cardiac surgery to minimize bleeding and to reduce exposure to blood products. We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences. METHODS In this multicenter, blinded trial, we randomly assigned ...