OBJECTIVE Massive pulmonary embolism is relatively rare but a potentially life-threatening condition. The purpose of this study was to analyse the outcome of pulmonary embolectomy in registered data from the Japanese Society of Pulmonary Embolism Research (JaSPER). METHODS From 1994 to 2006, 1661 cases of acute pulmonary embolism were registered in the JaSPER database. Retrospective analysis ...

Pulmonary thromboembolism (PTE) remains a diagnostic and therapeutic challenge for physicians. Anticoagulation with heparin remains as the cornerstone in its management, reserving thrombolysis for cases with hemodynamic impairment. The later has been associated with haemorrhagic complications and has proved beneficial when initiated within the first 48 hours of PTE; but there is little evidence...

1. Divisão de Pneumologia, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brasil. A 37-year-old female patient presented to the emergency department with a 3-week history of dyspnea, hypoxemia, pleuritic chest pain, and lower limb edema. She had no history of comorbidities and had had two normal pregnancies. There was no family history of thrombos...

Alteplase is standard therapy for patients with acute, massive pulmonary embolism. The novel plasminogen activator desmoteplase displays high fibrin specificity and selectivity for fibrinbound plasminogen. In a preclinical model desmoteplase was twice as potent with a shorter lysis time and lower reocclusion rate. We conducted a phase II study comparing 125, 180, and 250 microg/kg bodyweight de...

Objectives: Venous thromboembolis is a clinical condition that often occurs from deep vein thrombosis of lower extremity. The incidence of deep venous thrombosis in the etiology of pulmonary thromboembolism may be as high as 90%. Doppler ultrasonography of lower extremities is recommended generally to determinate the etiology of pulmonary thromboembolism. The aim of this study is to present the...

Swine flue is a highly contagious acute respiratory disease caused by a subtype of influenza A virus. Herein we present three patients with H1N1 infection complicated with pulmonary thromboembolism. The patients had chest pain and unexplained dyspnea. Imaging studies showed bilateral hilar predominance. Computed tomographic angiography confirmed bilateral thromboembolism (an unusual presentatio...

results the incidence of diagnosed thrombo-embolic complication was 32 of 1,153 admitted patients (2.8%; 95% confidence interval: 1.9 to 3.9) with a median interval of 14 days after anti-tb treatment initiation. the incidence of dvt and pte was 2% and 1%, respectively. thrombo-embolic events and dvt were more common in men than in women: 4.2% versus 1.3% (p = 0.003) and 3.5% versus 0.4%, respec...

Disseminated intravascular coagulation (DIC) is a pathologic condition associated with critical illnesses, including sepsis. Recent studies have suggested that endogenous cytokines and leukocytes are involved in major roles of its pathophysiology. We report a case of sepsis-induced DIC due to pneumonia that was associated with diffuse and selective thrombosis in pulmonary arteries, yielding to ...