Vertebrate eggs arrest at metaphase of the second meiotic division before fertilization under the effect of a cytostatic factor (CSF). This arrest is established during oocyte maturation by the MAPK kinase module, comprised of Mos, MEK, MAPKs and p90Rsk. Maintenance of CSF arrest at metaphase requires inhibitors of the anaphase-promoting complex (APC) like Emi1, which sequesters the APC activat...

Vertebrate eggs arrest at metaphase of the second meiotic division before fertilization under the effect of a cytostatic factor (CSF). This arrest is established during oocyte maturation by the MAPK kinase module, comprised of Mos, MEK, MAPKs and p90. Maintenance of CSF arrest at metaphase requires inhibitors of the anaphase-promoting complex (APC) like Emi1, which sequesters the APC activator ...

but W. E. Snawdon: This patient was first seen by me on the 18th August 1959, quite k I should mention that he had been a patient at the Dental Hospital for their a/ew.yearsI have his record card here from which I see he first came under Patie Wln? *n I953> so we know that for several years he was an apparently normal iwje and had routine conservative dentistry. I think in 1953 he came with a r...

Fig. 1. Bone marrow aspirate (A, May-Grunwald Giemsa stain, ×400) and biopsy (B, Haematoxylin-eosin stain, ×400) of patient 1 showing myeloid maturation arrest. 5. Farah C, Bulai Livideanu C, Jegu J, et al. Prevalence and prognostic value of cutaneous manifestations in patients with myelodysplastic syndrome. J Eur Acad Dermatol Venereol 2010;24: 1171-5. 6. Avivi I, Rosenbaum H, Levy Y, Rowe J. ...

The mammalian UV response results in rapid and dramatic induction of c-jun. Induction of a protooncogene, normally involved in mitogenic responses, by a genotoxic agent that causes growth arrest seems paradoxical. We now provide an explanation for the role of c-Jun in the UV response of mouse fibroblasts. c-Jun is necessary for cell-cycle reentry of UV-irradiated cells, but does not participate...

The arrest of Mycobacterium tuberculosis phagosome maturation in infected macrophages is a phenomenon of dual significance both for the pathogenesis of tuberculosis and as a model system to study interference of microbes with membrane trafficking and organelle biogenesis in host cells. Among other factors, compartment-specialized regulators of vesicular trafficking and other parts of membrane f...

BACKGROUND In some couples, not all retrieved oocytes mature, even after prolonged in vitro culture. The underlying mechanisms are not known, although ionophore treatment may alleviate metaphase I (MI) arrest in some mouse strains. We attempted to induce first polar body (PB) extrusion and fertilization using assisted oocyte activation (AOA) after ICSI in maturation-resistant human MI oocytes. ...

Methods Prospectively collected digital growth curves and menarche status of an inception cohort of 196 female patients with pSLE diagnosed <16 years and a minimal disease duration of 3 years were analysed. Abnormal growth was defined as i) one or more periods of growth arrest (<2 cm) lasting minimal 6 months, ii) more than one growth curve percentile difference between height at diagnosis and ...

The onset of development is marked by two major, posttranscriptionally controlled, events: oocyte maturation (release of the prophase I primary arrest) and egg activation (release from the secondary meiotic arrest). Using quantitative mass spectrometry, we previously described proteome remodeling during Drosophila egg activation. Here, we describe our quantitative mass spectrometry-based analys...