Knowledge representation was used to characterize beliefs in patients with Environmental Illness/Multiple Chemical Sensitivity (EI/MCS). EI/MCS patients, allergy and asthma patients, doctors and controls made relatedness judgments on concepts relevant to EI/MCS. Associative networks showed that EI/MCS patients viewed these concepts differently from others. Multiple chemical exposure was central...

AIMS To investigate mast cell distribution in normal adult skin to provide a reference range for comparison with mastocytosis. METHODS Mast cells (MCs) were counted in uninvolved skin adjacent to basal cell carcinomas and other dermatological disorders in adults. RESULTS There was an uneven distribution of MCs in different body sites using the anti-tryptase monoclonal antibody technique. Nu...

OBJECTIVE Intraplaque neovascularization and hemorrhage may facilitate plaque progression. We studied expression of basic fibroblast growth factor (bFGF), a potent angiogenic mediator, by mast cells (MCs) in human coronary plaques with increasing degrees of atherosclerosis. METHODS AND RESULTS Normal and atherosclerotic coronary segments were collected from 30 autopsied subjects. Immunohistoc...

Merkel cells (MCs) are located in the touch-sensitive area of the epidermis and mediate mechanotransduction in the skin. Whether MCs originate from embryonic epidermal or neural crest progenitors has been a matter of intense controversy since their discovery >130 yr ago. In addition, how MCs are maintained during adulthood is currently unknown. In this study, using lineage-tracing experiments, ...

The characteristics, importance, and molecular requirements for interactions between mast cells (MCs) and CD8(+) T cells have not been elucidated. Here, we demonstrated that MCs induced antigen-specific CD8(+) T cell activation and proliferation. This process required direct cell contact and MHC class I-dependent antigen cross-presentation by MCs and induced the secretion of interleukin-2, inte...

OBJECTIVE To review critically the scientific literature on multiple chemical sensitivity (MCS). Definitions of MCS vary but, for this review, a broad definition of MCS was adopted as symptoms in more than one organ system elicited by various unrelated chemicals at very low levels of exposure. METHODS A systematic literature search identified several hundred references from which key papers w...

The advent of more complicated control charting schemes has necessitated the use of Monte Carlo simulation (MCS) methods. Unfortunately, few sources exist to study effective design and validation of MCS methods related to control charting. This paper describes the design, issues, considerations and limitations for conducting normal-based control chart MCS studies, including choice of random num...

Circulation. 2017;135:e1145–e1158. DOI: 10.1161/CIR.0000000000000507 June 20/27, 2017 e1145 Mechanical circulatory support (MCS) offers a surgical option for advanced heart failure when optimal medical therapy is inadequate. MCS therapy improves prognosis, functional status, and quality of life.1,2 The INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) tracks patient...

Based on the known accumulation of mast cells (MCs) in B cell-dependent inflammatory diseases, including rheumatoid arthritis, we hypothesized that MCs directly modulate B cells. We show here that degranulated, and to a lesser extent naïve or IgE-sensitized, MCs activate both naïve and B cell receptor-activated B cells. This was shown by increased proliferation, blast formation, and expression ...