نتایج جستجو برای: mdh
تعداد نتایج: 619 فیلتر نتایج به سال:
BACKGROUND Multiple drug hypersensitivity (MDH) was first described in 1989 by Sullivan et al. as drug allergies to two or more chemically different drugs. So far, the diagnosis of MDH was associated almost exclusively with antibiotics and was defined based on history alone. AIMS OF THE STUDY The objective of this study was to prove MDH by two independent tests, namely patch (PT) and lymphocy...
The international maritime traffic of people and goods has often contributed to the spread of pathogens affecting public health. The Maritime Declaration of Health (MDH), according to the International Health Regulations (IHR) (2005), is a document containing data related to the state of health on board a ship during passage and on arrival at port. It is a useful tool for early detection of pub...
In the methylotrophic bacterium Methylobacterium extorquens strain AM1, MxaF, a Ca(2+)-dependent methanol dehydrogenase (MDH), is the main enzyme catalyzing methanol oxidation during growth on methanol. The genome of strain AM1 contains another MDH gene homologue, xoxF1, whose function in methanol metabolism has remained unclear. In this work, we show that XoxF1 also functions as an MDH and is ...
The nuclear-encoded chloroplast NADP-dependent malate dehydrogenase (NADP-MDH) is a key enzyme controlling the malate valve, to allow the indirect export of reducing equivalents. Arabidopsis thaliana (L.) Heynh. T-DNA insertion mutants of NADP-MDH were used to assess the role of the light-activated NADP-MDH in a typical C(3) plant. Surprisingly, even when exposed to high-light conditions in sho...
ENE duplication is an important evolutionary mechanism and may have led to large increases in genome size and diversity early in vertebrate evolution (OHNO 1970). The role of duplicate genes may be further elucidated by biochemical and genetic analyses of multigenic isozyme system in modern teleosts. Gene duplications are generally detected by the biochemical multiplicity of gene products. Appa...
BACKGROUND Subjects with drug hypersensitivity are sometimes simultaneously reactive to several drugs. This nosological entity is defined as multiple drug hypersensivity (MDH). Urticaria and angioedema are the commonest clinical manifestations of hypersensitivity drug reactions (HDR). These clinical signs are also pathognomonic of chronic idiopathic urticaria (CIU), whose pathogenetic mechanism...
Background Multiple drug hypersensitivity (MDH) has been defined as a hypersensitivity to two or more chemically unrelated drugs. This has been specially studied in IgE-mediated hypersensitivity reactions to antibiotics and more recently in T-cell-mediated reactions. However, studies focusing in MDH in large populations are lacking. The aim of our study was to describe a well-characterized grou...
Malate dehydrogenase (MDH) (EC 1.1.1.37) catalyzes the conversion of oxaloacetate and malate. This reaction is important in cellular metabolism, and it is coupled with easily detectable cofactor oxidation/reduction. It is a rather ubiquitous enzyme, for which several isoforms have been identified, differing in their subcellular localization and their specificity for the cofactor NAD or NADP. Th...
A modifier protein (M-protein), which increases the affinity of methanol dehydrogenase (MDH) for alcohols but decreases its affinity for formaldehyde, has been partially purified from Methylophilus methylotrophus and Paracoccus denitrificans. Analysis was complicated by non-protein factors in bacterial extracts that are able to mimic M-protein in one of its functions-that of increasing the acti...
Introduction The Minnesota Department of Health (MDH) needs to be able to collect, use, and share clinical, individual-level health data electronically in secure and standardized ways in order to optimize surveillance capabilities, support public health goals, and ensure proper follow-up and action to public health threats. MDH programs, public health departments, and health care providers acro...
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