Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons. One conopeptide analogue, termed NMB-1 for noxious mechanosensation blocker 1, selectively inhibits (IC(50) 1 microM) sustained mechanically activated currents in a subset of se...

Carbon activated powdered was prepared from activated carbon derived from olive stone. Then byusing the surface methodology, many parameters such as pH, furnace temperature (T), acid ratio,time of activation that affect on the qualities prepared activated carbon produced and its efficiencywere investigated. In addition, the adsorption of Congo Red onto the activated olive stone carbonactive was...

We examined the effects of mechanical stress, induced by a stream of bath solution, on evoked action potentials, electrical excitability, and Ca2+ currents in rat dorsal root ganglion neurons in culture with the use of the whole cell patch-clamp technique. Action-potential duration was altered reversibly by flow in 39% of the 51 neurons tested, but membrane potential and excitability were unaff...

As expected from the alloy design procedure, combined Twinning Induced Plasticity (TWIP) and Transformation Induced Plasticity (TRIP) effects are activated in a metastable β Ti-12(wt.%)Mo alloy. In-situ Synchrotron X-ray diffraction (XRD), electron backscatter diffraction (EBSD) and transmission electron microscopy (TEM) observations were carried out to investigate the deformation mechanisms an...

Mechanical ventilation of patients can be a life-saving treatment, but also imposes additional stress on the lung. Mitogen-activated protein kinases (MAPK) represent a family of protein kinases that become phosphorylated and activated by many different forms of stress. Using Western blot analysis, the present study analysed the effects of high distending pressure ventilation on the activation o...

Background: P2X4 receptor (P2X4R), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. Spinal nerve injury induces up-regulation of P2X4R on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. The present study was undertaken to determine whether paroxetine, an inhibitor of P2X4R, could ...

background: this study is the first research investigating the possible effect of pulsed power signals on the characteristics of cortical bone by comparing the mechanical properties of this type of bone pre and post expose to pulsed power. methods: a positive buck-boost converter was applied to generate adjustable high voltage, high frequency pulses (up to 500 v and 10 khz). the functional beha...

The effects of silica fume and sodium silicate-based activators (SFA SSA, respectively) with different Ms (SiO2/Na2O) values on the setting behavior, rheological, mechanical, microstructural properties alkali-activated slag cement (AASC) were investigated. Setting time test results showed that AASCs activated by SFA prolonged significantly an increase value opposite to SSA activation case. From...

Dynamic mechanical relaxation is a fundamental tool to understand the and physical properties of viscoelastic materials like glasses. Mechanical spectroscopy shows that high-entropy bulk metallic glass (La30Ce30Ni10Al20Co10) exhibits distinct β-relaxation feature. In present research, dynamic analysis thermal creep were performed using this material at temperature domain around β relaxation. Th...

BACKGROUND AND OBJECTIVES Mechanical stimulation and hormones act via interconnected signaling pathways to influence the function of bone cells. Estrogen receptor (ER) and β-catenin play important role in bone formation and have implicated in mechanotransduction in bone cells. To investigate the interaction between mechanotransduction and estrogenic signaling in mesenchymal stem cells (MSCs), t...