Systemically administered human recombinant erythropoietin (EPO) may have the potential to reduce the cognitive and behavioral symptoms of mechanical brain injury. In a series of studies, we address this possibility. We previously found that EPO given to fimbria-fornix transected rats at the moment of injury could substantially improve the posttraumatic acquisition of an allocentric place learn...

please cite this article as : moini zanjani t, saghaei e, ameli h, sabetkasaei m. anti-allodynic effect of nefopam and morphine in a rat model of neuropathic pain. novel biomed 2013;1:16-22. background: neuropathic pain is a chronic pain due to a disorder in the peripheral or central nervous system with different pathophysiological mechanisms. current treatments are not effective. here we compa...

Activation of spinal glial cells plays a crucial role in the pathogenesis of neuropathic pain. An administration of oxaliplatin, an important anticancer drug, often induces acute neuropathic cold hypersensitivity and/or mechanical hypersensitivity in patients. Gyejigachulbu-tang (GBT), a herbal formula comprising Cinnamomi Cortex, Paeoniae Radix, Atractylodis Lanceae Rhizoma, Zizyphi Fructus, G...

BACKGROUND Behavioral criteria that confirm neuropathic pain in animal injury models are undefined. Therefore, the authors sought clinically relevant measures that distinguish pain behavior of rats with peripheral nerve injury from those with sham injury. METHODS The authors examined mechanical and thermal sensory sensitivity, comparing responses at baseline to responses after spinal nerve li...

This article introduces the concept of combining both form (CAD models) and behavior (simulation models) of mechatronic system components into component objects. By composing these component objects, designers automatically create a virtual prototype of the system they are designing. This virtual prototype, in turn, can provide immediate feedback about design decisions by evaluating whether the...

Amazon's Mechanical Turk is an online labor market where requesters post jobs and workers choose which jobs to do for pay. The central purpose of this article is to demonstrate how to use this Web site for conducting behavioral research and to lower the barrier to entry for researchers who could benefit from this platform. We describe general techniques that apply to a variety of types of resea...

Introduction: Peripheral and central nerve injuries cause chronic neuropathic pain in many injured people besides motor disability. Exercise, as a behavioral and non-pharmacological treatment, has beneficial effects on people’s general health both for healthy and sick people. Therefore, this study was conducted to examine the effects of exercise on neuropathic pain induced by chronic cons...

introduction: neuropathic pain is one of the common complications of diabetes mellitus which is caused by impairment in nerve conductivity. the role of flavonoid and polyphenol compounds in treatment of neuropathic pain has been revealed, and extract of onion contains significant amounts of these compounds. the aim of this study was to investigate the effect of alcoholic extract of onion on dia...