Purpose: Blast-induced traumatic brain injury (bTBI) is one of the causes of death or permanent   invalidity which can occur unexpectedly in both military and civilian populations. This study   set out to conduct a combined Eulerian-Lagrangian computational analysis of the interaction   between a single planar blast wave and a human head in order to assess the extent of intracranial   shock w...

STUDY DESIGN In vivo strain techniques were used in an animal radiculopathy model. OBJECTIVE To quantify the severity of compressive nerve root injury and characterize its effect on resultant mechanical allodynia in a lumbar radiculopathy model. SUMMARY OF BACKGROUND DATA Clinical and experimental work indicate many factors contributing to radicular pain mechanisms, including mechanical inj...

purpose: blast-induced traumatic brain injury (btbi) is one of the causes of death or permanent   invalidity which can occur unexpectedly in both military and civilian populations. this study   set out to conduct a combined eulerian-lagrangian computational analysis of the interaction   between a single planar blast wave and a human head in order to assess the extent of intracranial   shock wav...

purpose: to determine the nature and types of household eye injuries. methods: we prospectively analyzed data from 100 consecutive patients with household eye injuries (104 eyes) referred to emergency room of farabi eye hospital during october 2003. standardized international classification of ocular trauma (birmingham eye trauma terminology) was used for classification. results: household ocul...

To what extent dorsal horn interneurons contribute to the modality specific processing of pain and itch messages is not known. Here, we report that loxp/cre-mediated CNS deletion of TR4, a testicular orphan nuclear receptor, results in loss of many excitatory interneurons in the superficial dorsal horn but preservation of primary afferents and spinal projection neurons. The interneuron loss is ...

Introduction: Nonphysiological mechanical loading may be a contributing factor to the initiation and progression of degenerative diseases of articular cartilage such as osteoarthritis. Previous studies have shown that impact loading can give rise to the "propagation" of cell death from impacted to nonimpacted tissue regions [1], perhaps related to the release of toxic oxygen species and induced...

Dos Santos, C. C. and A. S. Slutsky. Invited Review: Mechanisms of ventilator-induced lung injury: a perspective. J Appl Physiol 89: 1645–1655, 2000.—Despite advances in critical care, the mortality rate in patients with acute lung injury remains high. Furthermore, most patients who die do so from multisystem organ failure. It has been postulated that ventilator-induced lung injury plays a key ...

Neuronal nitric oxide synthase (nNOS) is a key enzyme for nitric oxide production in neuronal tissues and contributes to the spinal central sensitization in inflammatory pain. However, the role of nNOS in neuropathic pain remains unclear. The present study combined a genetic strategy with a pharmacologic approach to examine the effects of genetic knockout and pharmacologic inhibition of nNOS on...