Cytoskeletal actin assemblies transmit mechanical stresses that molecular sensors transduce into biochemical signals to trigger cytoskeletal remodeling and other downstream events. How mechanical and biochemical signaling cooperate to orchestrate complex remodeling tasks has not been elucidated. Here, we studied remodeling of contractile actomyosin stress fibers. When fibers spontaneously fract...

An experimental study of the mechanical response of frozen soft biological tissues to applied compressive stresses is presented. This study is related to the mechanical stresses that develop due to the contraction of frozen tissues in cryopreservation as well as in cryosurgical procedures. The main concept in this study is that the stresses associated with the constrained contraction of the fro...

BACKGROUND Adhesive systems are constantly subjected to mechanical and chemical stresses that negatively impact the integrity and durability of the dentine-adhesive interface. Despite the lack of evidence to support or reject the clinical indication for mechanical retention, the potential further contribution of these preparations to the behavior of the composite resin-sound dentine bond has be...

The mechanical behavior of cold rolled sheets is significantly related to residual stresses that arise from bending and unbending processes. Measurement of residual stresses is mostly limited to surface measurement techniques. Experimental determination of stress variation through thickness is difficult and time-consuming. This paper presents a closed form solution for residual stresses, in whi...

The ability to apply quantifiable mechanical stresses at the microscopic scale is critical for studying cellular responses to mechanical forces. This necessitates the use of force transducers that can apply precisely controlled forces to cells while monitoring the responses noninvasively. This paper describes the development of a micromanipulation workstation integrating two-photon, three-dimen...

deep rolling is a kind of mechanical surface treatments that can improve surface quality, dimensional accuracy and mechanical properties of the parts. compressive residual stresses generated by the process reduce the tensile stresses during loading into the workpiece. the distribution of residual stress induced by deep rolling can be influenced by rolling parameters; such as overlap of the roll...

T he evolution of organisms has been both constrained and facilitated by many internal and external mechanical limitations. Mechanical sensing systems used by primitive cells to ensure survival have been retained, often in modified form, in multicellular animals and in the tissues and organ systems of mammals to form specialized sensors that monitor both the internal state of the organism as we...

Many tissues in our body experience mechanical stresses caused by both internal and external forces. The skin, for example, must tolerate diverse mechanical insults. In this paper, we report a role for β-catenin in providing stability to epithelia under stress. Loss of β-catenin during epidermal development caused perinatal lethality. Mutant embryos up-regulated stress responses at sites of act...

Tin alloy-based anodes supported by inverse-opal nanoscaffolds undergo large volume changes from (de)lithiation during cyclic battery (dis)charging, affecting their mechanical stability. We perform continuum mechanics-based simulation to study the evolution of internal stresses and strains as a function of the geometry of the active layer(s): (i) thickness of Ni3Sn2 single layer (30 and 60 nm) ...

the object of this work is to present a study of the thermomechanical behavior of the automobile disc brake for the prediction of their resistance to fatigue. then, a study of purely mechanical dry contact between the disc and pads is developed with a good prediction becomes a major stake for the industrialists while modeling the loading and the boundary conditions around the disc.we used the s...