نتایج جستجو برای: mecom
تعداد نتایج: 105 فیلتر نتایج به سال:
Heterochromatin serves important functions, protecting genome integrity and stabilizing gene expression programs. Although the Suv39h methyltransferases (KMTs) are known to ensure pericentric H3K9me3 methylation, the mechanisms that initiate and maintain mammalian heterochromatin organization remain elusive. We developed a biochemical assay and used in vivo analyses in mouse embryonic fibroblas...
Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, Netherlands, Department of Psychiatry, Erasmus Medical Center, Rotterdam, Netherlands, Department of Epidemiology, Eras...
We identifieda fusionbetweenETV6 on l2pl3 and MDSJIEVIJ on 3q26 in a t(3;12)(q26;p13)found in two casesof myeloproliferative disor. der. The resultingchimerictranscriptconsistsof the first two exonsof ETV6 fused to MDSJ sequences, which in turn is fused to the second exon of the EVIl gene. It has recently been reported that MDS1 can be expressed in normal tissues both as a single gene and fused...
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