Intraocular medulloepithelioma of cilliary body is a nonhereditary neoplasm childhood arising from primitive medullary epithelium characterized by cords multi-layered neuroepithelial cells resembling the optic cup. It often present as loss vision, painful eye & leucocoria. Common signs include secondary glaucoma dislocated lens. About half patients undergo surgery before discovery this tumo...

Daniel S. Poon, Ehud Reich, Victoria M. Smith, Judith Kingston, M. Ashwin Reddy, John L. Hungerford, Mandeep S. Sagoo 1 Royal London Hospital, London, UK 2 Moorfields Eye Hospital, London, UK 3 St. Bartholomew’s Hospital, London, UK 4 Great Ormond Street Hospital, London, UK 5 UCL Institute of Ophthalmology, London, UK * Address for reprints: Mr Mandeep S. Sagoo, MB, PhD, FRCS (Ed), FRCOphth, M...

CASE REPORT We describe the unusual diagnosis of a ciliary body medulloepithelioma by histopathology of a subretinal membrane obtained from vitreoretinal surgery of a 10-year-old boy. The patient had a history of perforating trauma OS 2 years earlier, and both fundus exam and B-scan ultrasound revealed only a retinal detachment with a subretinal membrane. No detectable mass was present. DISCU...

Purpose Intraocular medulloepithelioma (IM), the second most common primary neuroepithelial tumor of the eye, can lead to blindness in the affected eye and in rare cases, is deadly. Intraocular medulloepithelioma lacks targetable biomarkers for potential pharmacologic therapy. The purpose of this study was to identify actionable, tumor-specific proteins for potential diagnostic or therapeutic s...