BACKGROUND The effectiveness of drugs aimed at counteracting cancer cachexia is generally tested in pre-clinical rodent models, where only the tumour-induced alterations are taken into account, excluding the co-presence of anti-tumour molecules that could worsen the scenario and/or interfere with the treatment. METHODS The aim of the present investigation has been to assess the efficacy of a ...

The title compound, C(24)H(34)O(4), is a precursor of Megestrol acetate. Ring A has a half-chair conformation [Q = 0.446 (3) Å, θ = 54.6 (4)° and ϕ = 9.5 (4)°]. Ring D adopts a 13β-envelope conformation [Q = 0.463 (2) Å and ϕ = 188.2 (3)°].

Acetyl coenzyme A synthetase, which catalyzes the biosynthesis of acetyl coenzyme A from acetat,e, adenosine triphosphate, and coenzyme A, has previously been obtained in highly purified form from bovine heart mitochondria (1). The enzyme appeared to be fairly homogeneous because only a single protein peak was detected in two chromatographic systems and the pattern observed in the analytical ul...

A rising concern among clinicians is treatment of unplanned weight loss in the elderly, especially given the predicted growth of this population over the next few decades. Unexpected weight loss in the geriatric patient worsens overall health outcomes. A variety of pharmacotherapeutic options are available for treatment; however, evidence underlying their use is limited, and none has gained app...

Malnutrition is a common clinical problem in dialysis patients. So far the management of malnutrition in this population has not been fully successful. The aim of the study was to evaluate the efficacy and safety of use of megestrol acetate suspension in malnourished dialysis patients. Twenty-six hypoalbuminemic (albumin < or = 3.8 g/dl) dialysis patients took 160 mg of megestrol acetate daily ...

Acetyl coenzyme A synthetase, which catalyzes the biosynthesis of acetyl coenzyme A from acetat,e, adenosine triphosphate, and coenzyme A, has previously been obtained in highly purified form from bovine heart mitochondria (1). The enzyme appeared to be fairly homogeneous because only a single protein peak was detected in two chromatographic systems and the pattern observed in the analytical ul...

The prolactin (PRL) release-inhibitory effects of progesterone, dexamethasone, megestrol acetate, and mifepristone (RU 38486) were studied in cultured pituitary tumor cells prepared from the 7315a and 7315b tumor. Both tumors contain similar numbers of estrogen and progesterone receptors, while only the 731Sa tumor also has glucocorticoid receptors. PRL release by the 731Sa tumor was stimulated...

In this work attempts were made to evaluate K+-SDS and hydrocolloid polymer-SDS interactions in flocculation of megestrol acetate dispersions to enhancetheir stability as a part of suspension formulation. Different dispersions of micronized megestrol acetate and SDS were prepared. KCl and KH2PO4 and their corresponding sodium salts were added to the dispersions and the preparations were evaluat...