This article reports on the effects of a new combined wet milling technique on the physicochemical properties of meloxicam (MEL). The influence of milling time on the particle size, the crystallinity, the morphology and the dissolution rate of MEL has been studied in the presence and absence of polyvinyl alcohol (PVA) as a stabilizer agent. Micronized MEL particles were produced in aqueous medi...

OBJECTIVE The influence of pinealectomy and long-term melatonin (MEL) administration on circadian oscillations of selected biochemical markers of bone metabolism [serum alkaline phosphatase (ALP) activity, carboxyterminal propeptide type I procollagen (PICP) and carboxyterminal telopeptide type I collagen (ICTP) concentrations as well as urinary excretion of hydroxyproline (HYP) and Ca] and pos...

The paper is devoted to the study of the behavior of capacitor type electrochemical system in the К(+)-containing aqueous electrolytes. Nanoporous carbon material (NCM) was used as the electrode material, obtained by carbonization of plant raw materials with the following chemical activation. Optimization of pore size distribution was carried out by chemical-thermal method using potassium hydro...

MATERIALS AND METHODS Tumors.—The tumor material used was derived from the hamster tumors which have been described by Fortner et dl. (l, 2) and had been carried for about a year in this laboratory. The following lines were used: amelanotic melanoma #3 (A. Mel. #3), amelanotic melanoma #4 (A. Mel. #4), renal adenocarcinoma #1 (R. Ca. #1). adrenal cortical carcinoma #4 (Ad. Ca. #4), cystadenoc...

Objective Biocompatible materials such as interconnected porous hydroxyapatite ceramics (IP-CHA) loaded with osteogenic cells and bioactive agents are part of an evolving concept for overcoming craniofacial defects by use of artificial bone tissue regeneration. Amongst the bioactive agents, melatonin (MEL) and basic fibroblast growth factor (FGF-2) have been independently reported to induce ost...

Well-defined nanoporous palladium (np-Pd) fabricated by a modified electrochemical dealloying procedure is demonstrated to be an excellent electrocatalyst material for reductive degradation of both carbon tetrachloride and chlorobenzene.

Material surface topography is an important factor for regulating cellular behaviour. Understanding the mechanism of how surface topography influences mammalian cells is critical for the development of medical implants and tissue engineering. In this study, we investigated the influences of nanoporous and microgrooved substrates on the morphology and migration of hepatic cell line, BEL-7402 cel...

W-doped TiO2 with nanoporous structure was synthesized by a one-step low temperature hydrothermal method using TiOSO4 and (NH4)6H2W12O40•xH2O as titanium and tungsten sources. Structure, morphology, specific surface area and chemical state of samples were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). W-doped nanoporo...