This paper presents the preparation and mechanical properties of compatibilized compositionally graded Polyethylene/ low density polyethylene (LDPE)/ modified montmorillonite (MMT) nanocomposites prepared by solution and melt mixing techniques. Use of polyethylene glycol as compatibilizer improves compatibility of modified montmorillonite and low density polyethylene.  Comparisons between two t...

Naproxen is a poor water soluble, non-steroidal analgesic and anti-inflammatory drug. The enhancement of oral bioavailability of poor water soluble drugs remains one of the most challenging aspects of drug development. Although salt formation, solubilization and particle size reduction have commonly been used to increase dissolution rate and thereby oral absorption and bioavailability of low wa...

The aim of the present work was to develop immediate release dosage form of the solid dispersion of glimperide (GLIM) for potential enhancement in the bioavailability. The solid dispersions of GLIM were prepared with PEG6000, PVP K30 and Poloxamer 188, in 1:1, 1:3 and 1:5 %w/w ratio by using solvent wetting and solvent melt method. The in vitro dissolution parameters (%DE10min, %DE30min, %DE60m...

Biocomposites of low-density polyethylene (LDPE) and polypropylene (PP) with 5–40wt% soy flour (SF) are produced by two-step single-screw extrusion (SSE) followed by solid-state shear pulverization (SSSP). The SSE-SSSP approach overcomes limitations with melt mixing, e.g poor SF dispersion and degradation, and limitations with single-step SSSP. Microscopy shows that SF is well dispersed in SSE-...

The objective of the present study is to formulate and evaluate roxithromycin tablets employing roxithromycin (ROX) solid dispersions. Dispersions of ROX in mannitol were prepared by different techniques like physical mixing, melting method, melt solvent method, kneading technique and common solvent method with drug and carrier ratio of 1:1, 1:2, 1:4 and 1:9. ROX tablets were formulated employi...

Nanocomposites of isotactic polypropylene (iPP) and date wood fiber were prepared after modification of the host matrix by reactive extrusion grafting of maleic anhydride. Chemical and mechanical treatment of date wood flour (WF) was conducted to obtain nanocrystalline cellulose. Layered silicates (clay) were partially intercalated with date wood fiber, and the modified layered silicate was use...

During the developmental process, there is an estimated 40 to 70% incidence of delay or failure for new drug entities due to poor biopharmaceutical properties such as poor solubility, poor permeability and poor chemical stability. Hot melt extrusion (HME) technology may provide the answer. HME, a solid-dispersion technology, has gained popularity in the pharmaceutical industry as a means of imp...

Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by the pharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and targeted drug delivery systems.HME is a solvent ...