OBJECTIVES In this study, the principles of quality by design (QbD) have been uniquely applied to a pharmaceutical melt extrusion process for an immediate release formulation with a low melting model drug, ibuprofen. METHODS Two qualitative risk assessment tools - Fishbone diagram and failure mode effect analysis - were utilized to strategically narrow down the most influential parameters. Se...

In present times, the pelletization technologies are giving much attention as they represent an efficient pathway for manufacture of new drug delivery system .It has good advantage over the conventional dosage form. Pelletization technique help in the formation of spherical beads or pellets having a diameter 0.5 -1.5 mm which can be eventually coated for preparation of modified release dosage f...

A melt-blended and melt-filtered real post-consumer and recyclable waste electrical and electronic equipment plastics blend (WEEEBR) was studied, where the WEEEBR contained mainly acrylonitrile-butadiene-styrene copolymer (~40 wt %), high impact polystyrene (~40 wt %) and polypropylene (~10 wt %). The main aim was to better understand the influence of different reprocessing conditions on the me...

Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large-scale manufacture. Current literature has primarily focused on the preparation and characterization of novel cocrystals typically containing only ...

Nylon 11 (PA11)/clay nanocomposites have been prepared by melt-blending, followed by melt-extrusion through a capillary. Transmission electron microscopy shows that the exfoliated clay morphology is dominant for low nanofiller content, while the intercalated one is prevailing for high filler loading. Melt rheological properties of PA11 nanocomposites have been studied in both linear and nonline...

Extrusion is a continuous process and successful economic production depends on maintaining stable output and melt quality at an accurately controlled rate. Current screw design technology, the use of DC drives, computerized controllers and raw material testing help to deliver the melt to the extrusion die at relatively constant temperature, pressure and viscosity. However, even the slightest v...