Nitric oxide (NO) is thought to be involved in spatial learning and memory in several brain areas such as hippocampus. This study examined the effects of post-training intrahippocampal microinjections of 1400W as a selective inducible nitric oxide synthase (iNOS) inhibitor on spatial memory, in both anesthetized and non-anesthetized situations in rats. In the present work, 4-day training trials...

It has been shown that pre-test systemic administration of morphine was able to reverse memory impairment induced by pre- or post-training morphine in an inhibitory avoidance paradigm. Since the recall of the learned information is possible only if the subject is in the same state as during the encoding phase, this kind of learning is known as state-dependent learning. Several drugs have been d...

background: cyclooxygenase (cox) enzyme known as a regulatory factor in synaptic plasticity. it has been reported that synaptic plasticity is one of the mechanisms involved in learning and memory processes. in the current study peripheral injection's effects of sodium salicylate (as a non selective cox inhibitor) on spatial learning and memory have been investigated. methods: four groups of mal...

background and objective: identifying the details of the injurious effects of alcohol seems to be decisive in nowadays with growing abuse of the substance. this study mainly aimed to assess the adverse effects of ethanol on the recalling of information in the wistar rats. materials and methods: male wistar rats (pasteur institute of iran) were evaluated using the novelty seeking behavior based ...

nitric oxide (no) is thought to be involved in spatial learning and memory in several brain areas such as hippocampus. this study examined the effects of post-training intrahippocampal microinjections of 1400w as a selective inducible nitric oxide synthase (inos) inhibitor on spatial memory, in both anesthetized and non-anesthetized situations in rats. in the present work, 4-day training trials...

dementia is a syndrome encompassing many intellectual domains that can be broadly defined as an overall decline in intellectual function including difficulties with language, simple calculations, planning and judgment and motor skills as well as loss of memory. a genetic cause is identified in only a minority of patients, but patients and their family members are frequently concerned about the ...

Background and Objective: Identifying the details of the injurious effects of alcohol seems to be decisive in nowadays with growing abuse of the substance. This study mainly aimed to assess the adverse effects of ethanol on the recalling of information in the Wistar rats. Materials and Methods: Male Wistar rats (Pasteur Institute of Iran) were evaluated using the novelty seeking behavior based ...