Coverings of the brain As introduced in the 2nd lecture, the brain is covered by three layers namely: dura mater, arachnoid, pia matter. The dura mater is of significance due to the venous sinuses and is the toughest layer/s (two layers in fact) – and its upper layer is directly attached to the periosteum. The blood vessels travel between the arachnoid and pia mater. The arachnoid and pia mater...

Hereditary transthyretin amyloidosis belongs to a group of diseases with an autosomal dominant type transmission and heterogeneous clinical picture, which depends on the gene mutation. The leptomeningeal form is rare phenotypic variant predominant involvement brain spinal cord meninges, as well cortical meningeal vessels. main manifestations this phenotype include cephalalgic syndrome, episodes...

Lyme disease, which is caused by infection with Borrelia burgdorferi and related species, can lead to inflammatory pathologies affecting the joints, heart, nervous systems including central system (CNS). Inbred laboratory mice have been used define kinetics of B . host immune responses in joints however similar studies are lacking CNS these animals. A tractable animal model for investigating ho...

The APOE-ε4 allele correlates with increased risk of Alzheimer disease (AD) and increased parenchymal amyloid plaques. We tested how the APOE genotype correlated with cerebral amyloid angiopathy (CAA) by analyzing 371 brains for parenchymal and meningeal CAA in 4 brain regions (frontal, parietal, temporal, and occipital neocortex). The overall severity of CAA was highest in the occipital lobe. ...