Tumor budding is a histological phenomenon encountered in various cancers, whereby individual malignant cells and/or small clusters of malignant cells are seen in the tumor stroma. Postulated to be mirror epithelial-mesenchymal transition, tumor budding has been associated with poor cancer outcomes. However, the vast heterogeneity in its exact definition, methodology of assessment, and patient ...

Mesenchymal gene expression in tumors has been implicated in cancer recurrence, metastasis, and poor prognosis of patients. The source of these mesenchymal signals has been mostly attributed to the epithelialto-mesenchymal transition-like phenotype of epithelial tumor cells. However, recent evidence from colorectal and other cancer transcriptome studies clearly shows that the mesenchymal gene e...

Objective(s): Growing evidences have indicated microRNAs as modulators of tumor development and aggression. On the other hand, a phenomenon known as epithelial-mesenchymal transition (EMT) that indicates a transient phase from epithelial-like features to mesenchymal phenotype is a key player in tumor progression.  In this study, we aimed to assess the potential impacts...

Epithelial-to-mesenchymal transition (EMT) endows epithelial cells with enhanced motility and invasiveness, allowing them to participate in many physiological and pathological processes. Epithelial-to-mesenchymal transition contributes to the generation of circulating tumor cells (CTCs) in epithelial cancers because it increases tumor cell invasiveness, promotes tumor cell intravasation and ens...

The invasion and spread of cancer cells are two the most notable characteristics malignant tumors. Recent studies suggest that epithelial-mesenchymal transition (EMT) has been linked to this significant occurrence. It is absence epithelial brow presence mesenchymal facial hair. aims present study were explore immunohistochemical staining vimentin E-cadherin ex vivo as EMT markers assess their p...

The epithelial-mesenchymal transition (EMT) has been postulated as a mechanism by which cancer cells acquire the invasive and stem-like traits necessary for distant metastasis. However, direct in vivo evidence for the role of EMT in the formation of cancer stem-like cells (CSC) and the metastatic cascade remains lacking. Here we report the first isolation and characterization of mesenchymal-lik...

malignant peripheral nerve-sheath tumor (mpnst) is a high-grade malignant tumor of ecto-mesenchymal origin comprising approximately 10% of soft-tissue sarcomas. they tend to occur associated with neurofibromatosis or sporadically. here we report a mpnst at an extremely rare location and behavior causing disappearance of the entire kidney. patient evaluation included clinical, biochemical and ra...

Soft tissue sarcomas of the hand and foot comprise a rare subgroup mesenchymal tumors with more favorable oncological prognosis. For this type tumors, several options surgical treatment exist depending on histological subtype, size local tumor advancement. Additionally, due to significant functional load distal parts limbs, techniques for these patients have specific characteristics. However, p...