multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by a complex immune response. because of the complex nature of ms pathogenesis, a panel of biomarkers derived from different platforms will be required to reflect disease-related alterations. monitoring and evaluation of molecules associated with the pathogenesis of the disease would provide useful ...

N6-Methyladenosine (m6A) is the most common modification of messenger RNA (mRNA) in mammals. It critically influences metabolism and plays an essential role virtually all types bioprocesses including gene expression, tissue development, self-renewal differentiation stem cells, stress response circadian clock control. a crucial carcinogenesis could be used as prognostic diagnostic tool target fo...

Messenger RNA levels in eukaryotes are controlled by multiple consecutive regulatory processes, which can be classified into two layers: primary transcriptional regulation at the chromosomal level and secondary, co- and post-transcriptional regulation of the mRNA. To identify the individual contribution of these layers to steady-state RNA levels requires separate quantification. Using mouse as ...

Abstract Bullous pemphigoid and psoriasis are two well‐characterised chronic autoimmune diseases that may be triggered by drugs, infections or vaccines. The coexistence of the is a rare event but more extraordinary if incited messenger RNA (mRNA) COVID‐19 vaccination. A 62‐year‐old Filipino male experiencing flare‐up his long‐standing vulgaris presented with new onset tense blisters on legs 2 d...

The RNA world hypothesis refers to the early period on earth in which RNA was central in assuring both genetic continuity and catalysis. The end of this era coincided with the development of the genetic code and protein synthesis, symbolized by the apparition of the first non-random messenger RNA (mRNA). Modern transfer-messenger RNA (tmRNA) is a unique hybrid molecule which has the properties ...

A major stage in the expression of genes is translation messenger RNA (mRNA), and regulation this process essential for protein production cells. How tightly controlled gene can be spatially temporally, particularly evident polar cells embryonic development. We need tools to dissect these complex processes, if we wish understand underlying links, especially difficulties brought on by malfunctio...

Messenger RNA (mRNA) has come into the spotlight due to its potential for addressing a staggering number of diseases, while lack effective and safe carriers in vivo delivery significantly limits clinical application. Herein, lipid-like nanoparticles (LLNs) containing three new cholesterol derivatives achieve liver targeting mRNA is investigated. The central composite design (CCD) used tailor fo...

$\ensuremath{-}1$ programmed ribosomal frameshifting ($\ensuremath{-}1\text{ }\text{ }\mathrm{PRF}$) is stimulated by structures in messenger RNA (mRNA), but the factors determining $\ensuremath{-}1\text{ }\mathrm{PRF}$ efficiency are unclear. We show that varies directly with conformational heterogeneity of stimulatory structure, quantified as Shannon entropy state occupancy, for a panel effic...

Ribosomes play a critical role in maintaining cellular proteostasis. The binding of messenger RNA (mRNA) to the ribosome regulates kinetics protein synthesis. To generate an understanding structural, mechanistic, and dynamical features mRNA recognition ribosome, we have analysed mRNA-protein interactions through structural comparison ribosomal complex presence absence mRNA. do so, compared 3-Di...

Vesicular stomatitis virus (VSV)-specific messenger ribonucleic acid (mRNA) species contain sequences of adenylate-rich RNA which are more heterogeneous in their migration through sodium dodecyl sulfate-polyacrylamide gels than the corresponding fractions from HeLa cell mRNA. VSV virion RNA contains no adenylaterich sequences. The possible role of such sequences in the mRNA species of a cytopla...