The progressive loss of kidney function is accompanied by metabolic acidosis. The relationship between metabolic acidosis, nutritional status, and oral bicarbonate supplementation has not been assessed in the Indian chronic kidney disease (CKD) population who are on maintenance hemodialysis (MHD). This is a single-center prospective study conducted in the Western part of India. Thirty-five pati...

BACKGROUND The effects of acute respiratory versus metabolic acidosis on the myocardium and their consequences on adrenoceptor stimulation remain poorly described. We compared the effects of metabolic and respiratory acidosis on inotropy and lusitropy in rat myocardium and their effects on the responses to α- and β-adrenoceptor stimulations. METHODS The effects of acute respiratory and metabo...

Amlal, Hassane, Sulaiman Sheriff, and Manoocher Soleimani. Upregulation of collecting duct aquaporin-2 by metabolic acidosis: role of vasopressin. Am J Physiol Cell Physiol 286: C1019–C1030, 2004. First published December 24, 2003; 10.1152/ajpcell.00394. 2003.—Metabolic acidosis is associated with alteration in fluid and electrolyte reabsorption in a number of nephron segments. However, the eff...

Background: Ethylene glycol is a toxic alcohol which is used in brake fluid, antifreeze, coolants, preservatives and chemical solvents. Ethylene glycol poisoning usually results in depression of the central nervous system, renal insufficiency and cardiopulmonary compromise, while laboratory findings include metabolic acidosis, increased anion gap, increased osmolar gap and calcium oxalate cryst...

Although hyperventilation is a well-known compensatory mechanism in metabolic acidosis, compensatory hypoventilation has been inconsistent and confroversial in metabolic alkalosis. Six healthy subjects were studied under baseline conditions and during steady-state metabolic acidosis (seven episodes) and alkalosis (14 episodes). Minute ventilation (yE) fell in metabolic alkalosis and rose in met...

mote the increased atherosclerosis described in CKD [12] . Observational studies show that low serum [HCO 3 ] is associated with increased incidence of hypertension [13] , a major contributor to cardiovascular disease. In addition, high dietary acid increases the risk for CKD patients with reduced GFR to develop metabolic acidosis [14] and increases the risk for subsequent development of hypert...