BACKGROUND Patients who have had a colorectal adenoma are likely to develop a metachronous adenoma and therefore need to be kept under surveillance. It is essential to avoid unnecessary examinations by tailoring the frequency of follow up examinations to individual risk. METHODS A total of 3134 patients undergoing endoscopic removal of colorectal adenomas were prospectively recorded on the Er...

BACKGROUND The consistent association between obesity and colorectal cancer is thought to be explained by metabolic disturbances common, but not exclusive, to the obese. METHODS We assessed the relation between metachronous neoplasia and the components of metabolic syndrome (MetS) as defined by the National Cholesterol Education Program's Adult Treatment Panel III in 2,392 participants of two...

BACKGROUND Screening programmes for contralateral carcinoma in situ (CIS) testis in patients with unilateral germ-cell cancer (GCC) have never been evaluated. We investigated the effect of screening for contralateral CIS in a large nation-wide, population-based study. PATIENTS AND METHODS A contralateral single-site biopsy was offered to 4130 patients in whom GCC had been diagnosed in 1984-20...

PURPOSE We performed a comparative analysis of the clinicopathologic features and oncologic outcomes of colorectal cancer patients with metachronous versus synchronous metastasis, according to the prognostic factors. METHODS Ninety-three patients who underwent curative resection for distant metastatic colorectal cancer were included in the study between December 2001 and December 2011. We ass...

Background Post-surgical colonoscopic surveillance is recommended every 1-2 years for patients diagnosed with colon cancer and Lynch syndrome. Patients electing to have a segmental versus colectomy IRA risk developing metachronous colon cancers. The rationale for frequent surveillance is to detect and remove polyps before pathologically advancing to cancer thereby reducing mortality. Does compl...

Background Lynch Syndrome (LS) correlated colorectal carcinoma (CRC) patients show a tendency towards the development of multiple and metachronous lesions and, for this reason, a surgical prophylactic treatment, as total colectomy, is warranted. Considering the quality of life of patients treated with total colectomy, it is essential to determine risk factors of metachronous CRC. Aim of the stu...

BACKGROUND & AIMS Patients diagnosed with colorectal cancer (CRC) are at risk for synchronous and metachronous lesions at the time of diagnosis or during follow-up evaluation. We performed a population-based study to evaluate the rate, predictors, and familial risk for synchronous and metachronous CRC in Utah. METHODS All newly diagnosed cases of CRC between 1980 and 2010 were obtained from t...

OBJECTIVES/HYPOTHESIS The primary objective was to determine the incidence of second metachronous head and neck cancers (HNC) following an index HNC and estimate their overall survival. STUDY DESIGN Retrospective cohort study. METHODS A total of 1,658 consecutive primary HNC patients diagnosed in 1986 to 1990 were identified through the prospectively maintained provincial BC Cancer Registry...

A previous genome-wide association study identified two novel esophageal squamous cell carcinoma (ESCC) susceptibility genes, ADH1B and ALDH2. We investigated the characteristics of ESCC, and the relationship between metachronous esophageal and/or pharyngeal squamous cell carcinoma (SCC) and the ADH1B & ALDH2 risk alleles. One hundred and seventeen superficial ESCC patients who underwent treatm...

BACKGROUND Metastatic nasopharyngeal carcinoma (NPC) is commonly treated with palliative chemotherapy. The purpose of this study was to review the feasibility of metastasectomy for metachronous pulmonary and hepatic metastases from NPC. METHODS We present 6 patients who developed metachronous metastases from NPC (4 patients with pulmonary metastases and 2 patients with hepatic metastases) and...