MetalDetector identifies CYS and HIS involved in transition metal protein binding sites, starting from sequence alone. A major new feature of release 2.0 is the ability to predict which residues are jointly involved in the coordination of the same metal ion. The server is available at http://metaldetector.dsi.unifi.it/v2.0/.

DNAzymes have shown great promise as a general platform for detecting metal ions, as many metal-specific DNAzymes can be obtained using in vitro selection. While DNAzyme-based metal sensors have found many applications in the extracellular environment, no intracellular application of DNAzyme sensors has yet been reported. Here, we demonstrate a novel type of metal ion sensor for intracellular m...

Disclosures: G W Blunn (5), Roberta Ferro Godoy (N), Hannah Wilson (3A Zimmer Biomet), Imran Khan (3A Zimmer Biomet), M J Coathup (N) INTRODUCTION: Data from the National Joint Registry of England and Wales (NJR) has shown that hip replacements with metal-onmetal (MoM) bearings, have significantly higher revision rates compared to metal-on-polyethylene (MoP). According to the NJR approximately ...

statement of problem: element release from dental casting alloys into the oral environment is of clinical concern and is considered to be a potential health problem to all patients. purpose: the aim of this study was to investigate the metallic ion release of four base metal alloys. materials and methods: two ni-cr (minalux and supercast) and two co-cr alloys (minalia and wironit) were examined...

A versatile approach to modify metal–organic framework nanoparticles (NMOFs) with nucleic acid tethers, using the “click chemistry” method is introduced. The nucleic acid-functionalized NMOFs are used to prepare stimuli-responsive carriers of loads (fluorescence probes or anti-cancer drugs). Two different stimuli-responsive nucleic acid-based NMOFs are presented. One system involves the prepara...

Silver and gold have been used for centuries as antimicrobial agents. The aim of the study was to investigate diametral tensile strength, microhardness, ion release and light transmission of experimental resin composites. Flowable dental composite SDR (Dentsply, United Kingdom) was modified by nanogold, nanosilver and silica addition. The metal ion release, light transmission study, microhardne...