Neurofibromatosis type 1 (NF1) has been associated with an increased risk for development of malignancy, especially malignant peripheral nerve sheath tumors. In addition, recently, literature has demonstrated an increased risk of breast cancer in women with NF1. The present paper shows a 53-year-old woman with NF1 who presented with metaplastic breast carcinoma and developed multiple metastases...

Invasive mammary carcinoma occurring after prophylactic mastectomy is rare. We report a case of a 42-year-old female diagnosed with metaplastic breast carcinoma after prophylactic mastectomy. Previously, the patient underwent bilateral mastec to my followed by reconstruction for unilateral invasive mammary carcinoma. One decade later, she presented with a 10 cm mass in the contralateral chest w...

BACKGROUND Fibromatosis-like metaplastic carcinoma is a newly described metaplastic breast tumor, literature on which is still evolving. CASE PRESENTATION A 77-year-old lady presented with a 2 x 2 cm mass with irregular margins in the upper and outer quadrant of left breast. Fine needle aspiration cytology (FNAC) from the lump was inconclusive. A lumpectomy was performed and sent for frozen s...

Metaplastic breast carcinomas are ductal carcinomas that undergo metaplasia into non-glandular growth patterns. They are very rare and account for less than 1% of all invasive breast carcinomas. Matrix-producing carcinoma is an extremely rare and aggressive subtype of metaplastic breast carcinoma that is characterized by a ductal carcinomatous component with direct transition to areas with cart...

BACKGROUND Metaplastic carcinoma of the breast is an extremely rare subtype of breast cancer with an incidence of <1% of all breast neoplasms. Metaplastic carcinoma with chondroid differentiation is the rarest among all histologic subtypes of breast cancer. We report a case of infiltrating ductal carcinoma with metaplastic features of chondroid differentiation. CASE PRESENTATION A 58-year-old...

Metaplastic breast carcinoma is uncommon and constitutes less than 5% of all breast cancers. The cancerous epithelium becomes non-glandular through metaplastic differentiation. There are various subtypes and the extent to which this process occurs varies. A case of a 52-year-old female patient is reported and the published literature is reviewed.

OBJECTIVE The purpose of this study is to investigate molecular subtyping and its implications on metaplastic carcinoma according to surrogate immunohistochemical (IHC) staining. METHODS Following tissue microarray analysis of 34 cases of metaplastic carcinoma, IHC staining for cytokeratin (CK) 5/6, epidermal growth factor receptor (EGFR), claudin-3, claudin-4, claudin-7, E-cadherin, STAT-1, ...

Matrix producing carcinoma of the breast is a unique subclass of metaplastic carcinoma, which is characterized by the existence of a ductal carcinomatous component with direct transition to areas showing cartilaginous or osseous differentiation lacking an interspersed spindle cell element. The tumor is of epithelial-myoepithelial histogenesis. It is said to carry a better prognosis compared to ...