BACKGROUND BAP1 and PBRM1 are frequently mutated in primary clear cell renal cell carcinoma (ccRCC) tumors; however, the frequency and clinical relevance of these mutations in metastatic ccRCC tumors is unknown. Additionally, while intra-tumor heterogeneity has been shown to be common in primary ccRCC, little is known regarding heterogeneity in metastatic ccRCC tumors. MATERIALS AND METHODS W...

despite many advances in the field of cancer treatment, intra-cranial tumor cases still have a poor prognosis. this research has been carried out in order to describe age and sex distributions and histopathological characteristics and site of intra-cranial tumors. we studied 425 patients with intra-cranial tumor whose samples were examined in pathology center of imam khomeini hospital from 1991...

a 33-year-old female presented with intermittent abdominal pain and severe attacks of lower gastrointestinal (gi) bleeding since 2 weeks. she has had history of irregular menses in last 3 months. in the labeled rbc-scan study, the bleeding site was detected in left upper quadrant (luq). in surgery, a tumor with the diameter of 2ã—1cm in a 65 cm distance of ligament of trietz was detected. in pa...

Metastatic tumors to the heart unlike primary cardiac tumors are not rare. Despite its frequency, cardiac metastasis is commonly detected only during autopsy as the symptoms of disseminated metastasis prevail over symptoms caused by cardiac metastasis and hence is overlooked most of the time. Tumors more commonly found metastasizing to the heart are malignancies of lung, breast, esophagus, lymp...

endometrial cancer generally carries a good prognosis. endometrial carcinoma more frequently metastasizes to the pelvic and para-aortic nodes. visceral metastases usually occur in the vagina and ovaries. distant metastases involve lungs and occur as a terminal event. this case report describes vulvalar metastasis of endometrial cancer to the clitoris. metastatic tumors of the vulva are rare. mo...

metastases of internal tumors to the oral cavity are unusual and in most cases involve maxilla and mandible. metastases to the gingival soft tissue are extremely rare. reporting a new clinical case of renal cell carcinoma (rcc) metastasis with an unusual site. metastatic involvement of gingival tissue with renal cell carcinoma is an extremely rare clinical event. it is usually associated with i...

AIMS To find specific magnetic resonance imaging (MRI) features to differentiate metastatic ovarian tumors from primary epithelial ovarian cancers. METHODS Eleven cases with metastatic ovarian tumors and 26 cases with primary malignant epithelial ovarian cancers were retrospectively studied. All features such as patient characteristics, MRI findings and biomarkers were evaluated. The differen...

BACKGROUND Uveal melanoma is the most common malignancy of the adult eye. The overall mortality rate is high because this aggressive cancer often metastasizes before ophthalmic diagnosis. Quantitative proteomic analysis of primary metastasizing and non-metastasizing tumors was pursued for insights into mechanisms and biomarkers of uveal melanoma metastasis. METHODS Eight metastatic and 7 non-...