3,4-methylenedioxymethamphetamine (MDMA), known as ecstasy, is a hallucinogen and stimulant illicit drug. Besides the systemic effects of this drug are well documented, it can also present with range oral side such ulcerations, to our knowledge, there only few cases involving mucosal ulcerations related MDMA abuse in literature. We encountered 38-year-old man widespread multiple attributed abus...

Methylenedioxymethamphetamine (MDMA) is an amphetamine analogue that preferentially stimulates the release of serotonin (5HT) and results in relatively small increases synaptic dopamine (DA). The ratio drug-stimulated DA, relative to 5HT, predicts abuse liability; drugs with higher DA:5HT ratios are more likely be abused. Nonetheless, MDMA a drug misused. Clinical preclinical studies have sugge...

Ecstasy normally contains 3,4 methylenedioxymethamphetamine (MDMA) that increases the levels of serotonin, dopamine, and epinephrine in the central nervous system with consequent adverse effects on the cardiovascular system. Herein, we presented a case of ecstasy abuse which resulted in two episodes myocardial infarction during a three month period; the second episode led to death due to thromb...

Background The popular recreational abuse drug 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') produces acute and long-lasting deficits in several markers of the serotonergic (5-HT) system. BDNF (brain derived neurotrophic factor) is a prominent trophic factor of serotonergic fibers. The aim of this study was to characterize the damage of serotonergic fibers in the frontoparietal cortex and...

A case of an apparently natural death in association with the use of an MDMA (3,4-methylenedioxymethamphetamine) is reported. The pathophysiology of the death and the pharmacology of the drug are presented. An overview of the certification of such cases is briefly presented.