Background and Objectives: The instructions of the manufacturer showed that metronidazole infusion solution (5mg/mL) is incompatible with few drugs. This study aimed to determine the physical and chemical compatibilities of metronidazole infusion with commonly used intravenously administered physiological solutions. Methods: Metronidazole injection in a commercially available concentration of 5...

Metronidazole has been used for the treatment of infections for >45 years and is still successfully used for the treatment of trichomoniasis, amoebiasis, and giardiasis. Anaerobic bacterial infections caused by Bacteroides species, fusobacteria, and clostridia respond favorably to metronidazole therapy. Good clinical results in the treatment of vaginosis due to Gardnerella vaginalis have also b...

Metronidazole has been used clinically for over 50 years as an antiparasitic and broad-spectrum antibacterial agent effective against anaerobic bacteria. However resistance to metronidazole in parasites and bacteria has been reported, and improved second-generation metronidazole analogues are needed. The copper catalysed Huigsen azide-alkyne 1,3-dipolar cycloaddition offers a way to efficiently...

background: due to high occurrence of bacterial vaginosis among women and its resistance to drug we need a new treatment regimen for improving the efficacy of present treatments. the objective of this study was to investigate the comparison between metronidazole and the combination of metronidazole and probiotic on the treatment of bacterial vaginosis. methods: this clinical-experimental study ...

Clinical trials were carried out in order to determine the value of metronidazole in preventing the development of anaerobic infections after surgery. Following a successful controlled trial of hysterectomy patients, among whom the prophylactic use of oral metronidazole resulted in a reduction of the anaerobic sepsis rate from 25% to nil, further trials were carried out with patients having urg...

Sir, Surveys of antimicrobial susceptibilities of isolates of the Bacteroides fragilis group showed that isolates were usually susceptible to metronidazole.1 Metronidazole-resistant phenotypes have rarely been reported. Here we report B. fragilis bacteraemia with reduced susceptibility to metronidazole developing during treatment. A 70-year-old man was admitted for excision of rectal adenoma. P...

Interactions between metronidazole and amoxicillin, metronidazole and its hydroxymetabolite, and amoxicillin and the hydroxymetabolite of metronidazole were investigated with checkerboard titrations in combination with accurately determined MICs and MBCs. Actinobacillus actinomycetemcomitans was used as the test organism. Synergism was found for all three combinations. Fractional inhibitory con...

objective: due to the high incidence of bacterial vaginosis (bv) and its resistance to chemical medications and considering the anti-bacterial and anti-fungal effects of myrtus communis, the present study aimed to compare the therapeutic effects of the vaginal gel of m. communis 2% (in metronidazole base) with metronidazole vaginal gel 0.75% alone on bv.materials and methods: this research was ...

Metronidazole is one of the rare examples of a drug developed against a parasite which has since gained broad use as an antibacterial agent (24). Briefly, at Rhone-Poulenc labs in France, extracts of Streptomyces spp. were screened for activity against Trichomonas vaginalis, a cause of vaginal itching. Azomycin, a nitroimidazole, was identified, and metronidazole, a synthetic derivative, was us...

A double blind study compared the efficacy of metronidazole in two doses (20 mg/kg, 10 mg/kg) with placebo in patients with Crohn's disease. One hundred and five patients participated but only 56 completed the 16 week study -21 were withdrawn for deterioration of symptoms, 17 for adverse experiences, and 11 for protocol violation. Significant improvement in disease activity as measured by the C...