نتایج جستجو برای: mhc class ii

تعداد نتایج: 943960  

Journal: :Journal of applied physiology 2006
S Mayr C R Walz P Angele T Hernandez-Richter I H Chaudry F Loehe K W Jauch M K Angele

Several studies indicate that cell-mediated immune responses, i.e., macrophage (MPhi) cytokine release capacities, myosin heavy chain (MHC) class II (Ia) expression, etc., are suppressed after trauma-hemorrhage in male mice. Testosterone has been shown to be responsible for the depression of MPhi cytokine responses in males after trauma-hemorrhage. Antigen presentation via MHC class II plays a ...

Journal: :Journal of biochemistry 2015
Noriko Arase Hisashi Arase

The major function of major histocompatibility complex (MHC) class II molecules is the presentation of peptide antigens to helper T cells. However, when misfolded proteins are associated with MHC class II molecules in the endoplasmic reticulum, they are transported to the cell surface by MHC class II molecules without processing to peptides. Of note, misfolded proteins complexed with MHC class ...

Journal: :International immunology 2013
Yan Jiang Noriko Arase Masako Kohyama Kouyuki Hirayasu Tadahiro Suenaga Hui Jin Maki Matsumoto Kyoko Shida Lewis L Lanier Takashi Saito Hisashi Arase

Nascent MHC class II molecules are associated with the invariant chain and are transported to the endolysosomal pathway, where MHC class II molecules acquire peptide antigens. On the other hand, misfolded endoplasmic reticulum (ER) proteins are generally degraded in the cells and are neither expressed on the cell surface nor secreted. Here, we found that MHC class II molecules associate with so...

Journal: :The Journal of Experimental Medicine 2001
Karen Honey Alexander Rudensky

Recognition of antigen by CD4 ϩ T cells requires presentation of short peptide fragments in the context of het-erodimeric MHC class II molecules (1, 2). Antigen presentation by MHC class II molecules is pivotal to the induction of adaptive immune responses, peripheral tolerance , and central tolerance, as well as being required for CD4 ϩ T cell survival (1–3). Constitutive expression of MHC cla...

Journal: :The Journal of clinical investigation 1996
J J Letterio A G Geiser A B Kulkarni H Dang L Kong T Nakabayashi C L Mackall R E Gress A B Roberts

The progressive inflammatory process found in transforming growth factor beta1 (TGF-beta1)-deficient mice is associated with several manifestations of autoimmunity, including circulating antibodies to nuclear antigens, immune complex deposition, and increased expression of both class I and class II major histocompatibility complex (MHC) antigens. The contribution of MHC class II antigens to the...

Journal: :Archivum immunologiae et therapiae experimentalis 2001
Y Liu P Zheng

Tumor expression of major histocompatibility complex antigen (MHC) class I and class II is not essential for the induction of memory T cells. However, induction of MHC class I-restricted effector cytotoxic T cells (CTL) appears dependent on MHC class I expression on tumors. Moreover, the effector function of tumor-specific CTL requires direct recognition of the tumor. In contrast, both the indu...

Journal: :Advances in cancer research 2005
Marije Marsman Ingrid Jordens Alexander Griekspoor Jacques Neefjes

Tumor vaccine development aimed at stimulating the cellular immune response focuses mainly on MHC class I molecules. This is not surprising since most tumors do not express MHC class II or CD1 molecules. Nevertheless, the most successful targets for cancer immunotherapy, leukemia and melanoma, often do express MHC class II molecules, which leaves no obvious reason to ignore MHC class II molecul...

Journal: :The Journal of Experimental Medicine 2000
Kayo Inaba Shannon Turley Tomonori Iyoda Fumiya Yamaide Susumu Shimoyama Caetano Reis e Sousa Ronald N. Germain Ira Mellman Ralph M. Steinman

During their final differentiation or maturation, dendritic cells (DCs) redistribute their major histocompatibility complex (MHC) class II products from intracellular compartments to the plasma membrane. Using cells arrested in the immature state, we now find that DCs also regulate the initial intracellular formation of immunogenic MHC class II-peptide complexes. Immature DCs internalize the pr...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Torsten B Meissner Amy Li Amlan Biswas Kyoung-Hee Lee Yuen-Joyce Liu Erkan Bayir Dimitrios Iliopoulos Peter J van den Elsen Koichi S Kobayashi

MHC class I plays a critical role in the immune defense against viruses and tumors by presenting antigens to CD8 T cells. An NLR protein, class II transactivator (CIITA), is a key regulator of MHC class II gene expression that associates and cooperates with transcription factors in the MHC class II promoter. Although CIITA also transactivates MHC class I gene promoters, loss of CIITA in humans ...

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