Diabetic retinopathy is a serious complication of diabetes and major cause of blindness. Therefore early detection through regular screening will be highly beneficial in effectively controlling the progress of the disease. Microaneurysms are the early signs of Diabetic retinopathy and appear as mall red dots. The number of microaneurysms gives the severity of the disease. Early microaneurysm de...

Individuals with diabetes are more likely to develop Diabetic Retinopathy (DR), a chronic ailment that can lead blindness if left undiagnosed. Early-stage (DR) is characterized by Microaneurysms (MA), which appear as tiny red lesions on the retina. This paper investigates unique approach for automated early identification of microaneurysms in eye images. A ensemble classifier technique suggeste...

With progression of disease the capillaries of the arterial side of the retinal circulation show increased vasoregression, with cell loss and closure. Simultaneously, the number of microaneurysms increases, and the areas of capillary closure enlarge. As they enlarge, they are seen to be crossed by the remaining enlarged capillaries, which appear to act as arteriovenous shunts, receiving the blo...

With progression of disease the capillaries of the arterial side of the retinal circulation show increased vasoregression, with cell loss and closure. Simultaneously, the number of microaneurysms increases, and the areas of capillary closure enlarge. As they enlarge, they are seen to be crossed by the remaining enlarged capillaries, which appear to act as arteriovenous shunts, receiving the blo...

Diabetic Retinopathy (DR) is the leading cause of blindness in adults around the world today. Early detection (that is, screening) and timely treatment have been shown to prevent visual loss and blindness in patients with retinal complications of diabetes. The basis of the classification of different stages of diabetic retinopathy is the detection and quantification of blood vessels and hemorrh...

Purpose To develop an automated method of localizing and discerning multiple types of findings in retinal images using a limited set of training data without hard-coded feature extraction as a step toward generalizing these methods to rare disease detection in which a limited number of training data are available. Methods Two ophthalmologists verified 243 retinal images, labeling important su...

The earliest histopathologic signs of diabetic retinopathy include selective loss of intramural pericytes and thickening of capillary basement membranes. Previous evidence from animal models indicated that aldose reductase inhibitors could prevent these capillary wall lesions, but only recently have aldose reductase inhibitors been tested for prevention of the subsequent retinal complications o...

The decorrelation signals in optical coherence tomography angiography (OCTA) are derived from the flow of erythrocytes and concomitantly delineate the retinal vasculature. We compared the structural and functional characteristics of vascular lesions visualized in fluorescein angiography (FA), OCTA, and en-face OCT images in 53 eyes (28 patients) with diabetic retinopathy (DR). The foveal avascu...