Recently, we demonstrated chromosome instability (CIN) in human cleavage stage embryogenesis following in vitro fertilization (IVF). CIN not necessarily undermines normal human development (i.e. when remaining normal diploid blastomeres develop the embryo proper), however it can spark a spectrum of conditions, including loss of conception, genetic disease and genetic variation development. To s...

Introduction: In Iran, invasive nontyphoidal Salmonella (iNTS) disease causes severe bacteremic illness among children <5 years old. The global yearly incidence of iNTS disease in children was reported to be in the 3.4 (range&nbsp; 2.1-6.5) million cases,&nbsp; (overall incidence 49 cases (range 30-94) per 100,000 population), the iNTS case-fatality ratio (CFR) of 20% yielded 681,316&nbsp; deat...

background: aflatoxin b1 (afb1) is a toxic metaboliteproduced by aspergillus species that contaminates a wide range ofagricultural products. objectives: this study was designed todevelop a rapid and highly sensitive immunoassay method inmicroarray format for quantitative detection of afb1 to evaluatethe potential of microarray platform for high-throughput screening,which can be beneficial in fo...

Molecular pathogenomic analysis of the human bacterial pathogen group A Streptococcus has been conducted for a decade. Much has been learned as a consequence of the confluence of low-cost DNA sequencing, microarray technology, high-throughput proteomics, and enhanced bioinformatics. These technical advances, coupled with the availability of unique bacterial strain collections, have facilitated ...

background classification of cancer subtypes by means of microarray signatures is becoming increasingly difficult to ignore as a potential to transform pathological diagnosis nonetheless, measurement of indicator genes in routine practice appears to be arduous. in a preceding published study, we utilized real-time pcr measurement of indicator genes in acute lymphoid leukaemia (all) and acute my...

b a c k g r o u n d  & aim: it is very helpful to classify and predict the clinical  category  of a sample based  on  its  gene  expression  profile.  this  study  was  conducted  to predict  tissues  of colorectal adenoma,  adenocarcinoma,  and  paired  normal  in  colon  based  on  microarray  data  using  nearest shrunken centroid method. methods   &  materials:    in  this  study,   the  co...

With the lowering cost and the increasing discoveries, genomics research filed has materialized personal genome era. Especially, microarray gene expression platform has already made several success stories for prognosis/diagnosis in medical contexts. However, the genome expression profiles, although having extensive information, still not be used in usual clinical context due to its complexity....