an agar well diffusion bioassay method for determination of clarithromycin in human plasma, using micrococcus luteus atcc 9341 as the assay organism, was compared with a selective high-performance liquid chromatographic (hplc) method with uv detection. spiked plasma was used to prepare standard and control samples for both methods. the results of the bioassay analyses with spiked plasma samples...

Biomarkers have the potential to expedite drug development, increase patient safety, and optimize clinical response. Yet few have achieved regulatory qualification. A survey was conducted to clarify industry's perspective on biomarker qualification and identify the most promising biomarkers for drug development. The results across toxicities/clinical areas highlight challenges in regulatory qua...

The first nonclinical drug development tool (DDT) advanced by the Critical Path to TB Drug Regimens (CPTR) Initiative through a regulatory review process has been endorsed by leading global regulatory authorities. DDTs with demonstrated predictive accuracy for clinical and microbiological outcomes are needed to support decision making. Regulatory endorsement of these DDTs is critical for drug d...

‎In this paper, using the idea of convexificators, we study boundedness and nonemptiness of Lagrange multipliers satisfying the first order necessary conditions. We consider a class of nons- mooth fractional programming problems with equality, inequality constraints and an arbitrary set constraint. Within this context, define generalized Mangasarian-Fromovitz constraint qualification and sh...

BACKGROUND Nosocomial infections represent one of the challenging problems of modern medicine. Healthcare providers play an important role in the transmission of these infections on their hands, clothing and equipment. Modern security systems require personnel to wear clearly displayed identity (ID) tags, and to have an easily accessible access disc. These access and ID tags are often worn arou...

Dual characterizations of the containment of a convex set with quasiconvex inequality constraints are investigated. A new Lagrange-type duality and a new closed cone constraint qualification are described, and it is shown that this constraint qualification is the weakest constraint qualification for the duality.

the objective of this study was to assess the microbial contamination of razavi khorasan (iran) hot red pepper. the natural occurrence of aflatoxins and ochratoxin a in those samples was also investigated. for this purpose, 36 samples of this kind of pepper were collected from a farm and sun-dried. standard and established methods were used for both microbiological analyses and mycotoxins ident...

Most developed countries have already accepted‘’ Competency’’ as the major factor in making management more competitive, therefore they have discovered the importance of Qualification Models and their application to cause human resources growth. Consequently, their aim is to improve the qualification of their human resources, and to reach this end, considering different ways of assessing compet...

We considered that a query of this year’s Genomics track consists of two parts, target and qualification. A target refers to any instance of a certain entity type and the qualification refers to the condition that the target needs to satisfy in order to be qualified as an answer to the query. For example, the target and qualification of the query “What [ANTIBODIES] have been used to detect prot...