The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) is selectively expressed in aldosterone target tissues, conferring aldosterone selectivity for the mineralocorticoid receptor. A diminished activity causes salt-sensitive hypertension. The mechanism of the variable and distinct 11β-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) expression in the cortical collecting duct is poorly...

To explore the function of kaempferol on lung cancer cell A549 and microRNA-199 variation is objective study. The proliferation was detected by counting kit-8. expression mammalian target rapamycin, phosphorylated light chain 3-?/?, beclin-1, B-cell lymphoma 2 2-associated X protein showed Western blot. determined quantitative polymerase reaction. adenocarcinomic human alveolar basal epithelial...

mirs are 17-25 nucleotide non-coding rnas. these rnas target approximately 80% of protein coding mrnas. mirs control gene expression and altered expression of them affects the development of cancer. mirs can function as tumor suppressor via down-regulation of proto-oncogenes and may function as oncogenes by suppressing tumor suppressors. myeloproliferative neoplasias (formerly known as chronic ...

objective: different signaling pathways have been identified that are involved in the cellular response to opiates. the mitogen-activated protein kinase pathway is one of the most important signaling pathways underlying the neuronal response to opiates. micrornas (mirnas) are considered to be post-transcriptional regulators of gene expression with paramount significance, which plays key roles i...

Drug resistance is the leading cause of death in prostate cancer patients. Therefore, exploring mechanism underlying drug and identifying novel therapeutic targets are urgently needed. Long non-coding ribonucleic acid disrupted renal carcinoma 3 acts as a tumor suppressor gene several types. However, to date, no study has investigated biological function long cancer. Gene expression was detecte...

endothelial cells present in brain are unique and differ from other peripheral tissues in a number of ways, which ensures specific brain endothelial barrier properties. endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation. various micrornas (mirna) have been discovered in different cellular components of the blood bran barrier (bbb). mirnas a...

micrornas are highly conserved small non-coding regulatory rnas that involve in post transcriptional regulating of gene expression during different cellular mechanisms. aberration of mir-218 expression during tumorigenesis of different solid tumors has been reported by numerous studies. in current systematic review article, by using the terms “mir-218” and “cancer” we first searched for english...