Glycemic control is the primary mediator of diabetic microvascular complications and also contributes to macrovascular complications. A new study (see related article beginning on page 1049) reveals a previously unrecognized association between oxidant activation of poly(ADP ribose) polymerase (PARP) and upregulation of known mediators of glycemic injury. Inhibitors of PARP may have potential t...

OBJECTIVE People with diabetes frequently develop vascular disease. We investigated the relationship between blood 25-hydroxyvitamin D (25OH-D) concentration and vascular disease risk in type 2 diabetes. RESEARCH DESIGN AND METHODS The relationships between blood 25OH-D concentration at baseline and the incidence of macrovascular (including myocardial infarction and stroke) and microvascular ...

Current guidelines for treating patients with type 2 diabetes mellitus are based on glycemic standards derived from epidemiologic data; however, the course of the disease, from prediabetes to end-stage complications, is not the same in all patients. Microvascular complications, including nephropathy, retinopathy, and neuropathy, are strongly related to hemoglobin A1c (HbA1c). However, vascular ...

Diabetes mellitus is a metabolic disease presenting growing prevalence worldwide. Oxidative stress involved in the development of micro- and macrovascular complications diabetic patients. Several pro-oxidative pathways contribute to production reactive oxygen species which can damage different biomolecules variety inflammatory cytokines are also aggravation manifestations. COVID-19 infection en...

Introduction/Aims: Microvascular and macrovascular complications lead to recurrent hospital admissions, hospitalizations, disability, death in the course of type 2 diabetes mellitus (T2DM). Triglyceride HDL cholesterol ratio (THR) is associated with insulin resistance. We aimed find out whether there a relationship between THR diabetic patients T2DM. Methods: Patients T2DM were enrolled study. ...

C-reactive protein (CRP), fibrinogen, and interleukin-6 (IL-6) are associated with cardiovascular disease (CVD) and death in general populations. However, studies of these factors in type 2 diabetes are limited. We studied their associations with the risk of major macrovascular events, microvascular complications, and mortality in patients with type 2 diabetes who participated in the Action in ...

Women with type 1 or type 2 diabetes mellitus should be prescribed a contraceptive that has little to no impact on carbohydrate and lipid metabolism and that has a very low risk profile for microvascular and macrovascular complications. However, it is unknown whether progestogen-only, combined estrogen and progestogen, or nonhormonal contraceptives vary in terms of effectiveness, adverse effect...

OBJECTIVE A protective effect of residual beta-cell function on microvascular complications of type 1 diabetes has been suggested. Our aim was to retrospectively evaluate the association of fasting plasma C-peptide values with micro- and macrovascular complications. RESEARCH DESIGN AND METHODS We recruited a clinic-based cohort of 471 type 1 diabetic patients born after 1945 and cared for in ...

BACKGROUND The purpose of this study was to assess actual barriers to blood glucose control in patients with type 2 diabetes mellitus and to investigate barrier-related factors in an exploratory manner. METHODS This cross-sectional study assessed patients with type 2 diabetes mellitus treated as outpatients at medical institutions within Fukuoka Prefecture, Japan. Barriers to blood glucose co...

OBJECTIVE To further knowledge of diabetes management in family practice. DESIGN Retrospective, observational chart audit study. SETTING Southwestern Ontario. PARTICIPANTS A random sample of non-academic family physicians and a random selection of their patients with type 2 diabetes mellitus. MAIN OUTCOME MEASURES Glycemic control as measured by Hb A1C and adherence to recommendations in clinic...