To elucidate the effects of endurance training on circulating irisin levels in young and middle-aged/older adults, and to determine the association between endurance training-induced alteration of irisin and reduction in body fat. Twenty-five healthy young (age 21 ± 1 years; 16 men, 9 women) and 28 healthy middle-aged/older adults (age 67 ± 8 years; 12 men, 16 women) participated in the study. ...

In this paper, we model the associations of childhood health on adult health and socio-economic status outcomes in China using a new sample of middle aged and older Chinese respondents. Modeled after the American Health and Retirement Survey (HRS), the CHARLS Pilot survey respondents are 45 years and older in two quite distinct provinces-Zhejiang, a high growth industrialized province on the Ea...

THE PREVALENCE OF SLEEP DISORDERED BREATHING (SDB) IN OLDER ADULTS IS HIGHER THAN IN MIDDLE-AGED ADULTS. IN A COMMUNITY-DWELLING population of older adults aged 65-95 years, Ancoli-Israel et al reported a SDB prevalence (apnea-hypopnea index, or AHI, ≥20) of 51% in men and 39% in women.1 In contrast, estimates of SDB in middle-aged adults are generally less than 10%2; side-by-side comparison st...

This article provides evidence about the quality of retrospective childhood health histories given to respondents in the Health and Retirement Survey (HRS) and the Panel Study of Income Dynamics (PSID). Even though information on early life health events is critical, there is legitimate skepticism about the ability of older respondents to remember specific health problems that they had during c...

A positive association between intelligence (IQ) and height has been reported previously. It is generally assumed that this association reflects the effect of childhood environment on IQ, but there is still little research supporting directly this hypothesis. We studied the association between height and IQ in 209 Dutch twin pairs at the ages of 5, 7, 10 and 12 years, 208 twin pairs at 16 and 1...

This study investigated the modifications in non-rapid eye movement (NREM) sleep electroencephalogram (EEG) power in 54 subjects, from children to middle-aged adults. Spectral analyses were performed on 5 h of NREM sleep. A marked decrease of absolute slow-wave activity (SWA) was observed with increasing age; children had significantly more SWA than adolescents, young and middle-aged adults. Th...

PURPOSE Functional measures are needed that are applicable to middle-aged adults with neurological disorders who are on the threshold of disability. One potential measure is the Continuous Scale Physical Functional Performance Test (CS-PFP), which has been normalized and validated to older adults but performance is unknown for adults younger than the age of 65 years with and without neurologica...

BACKGROUND Physical disability is increasingly recognized as an adverse health consequence of type 2 diabetes in older adults. We studied the effect of diabetes on disability in middle-aged and older adults to: 1) characterize the association of diabetes with physical disability in middle-aged adults, and 2) determine the extent to which the effect of diabetes is explained by related covariates...