MicroRNAs are short non-coding RNAs that can regulate gene expression during various crucial cell processes such as differentiation, proliferation and apoptosis. Changes in expression profiles of miRNA play an important role in the development of many cancers, including CRC. Therefore, the identification of cancer related miRNAs and their target genes are important for cancer biology research. ...

BACKGROUND The etiology and pathophysiology of endometriosis remain unclear. Accumulating evidence suggests that aberrant microRNA (miRNA) and transcription factor (TF) expression may be involved in the pathogenesis and development of endometriosis. This study therefore aims to survey the key miRNAs, TFs and genes and further understand the mechanism of endometriosis. METHODS Paired expressio...

MicroRNAs represent ~22 nt long endogenous small RNA molecules that have been experimentally shown to regulate gene expression post-transcriptionally. One main interest in miRNA research is the investigation of their functional roles, which can typically be accomplished by identification of mi-/mRNA interactions and functional annotation of target gene sets. We here present a novel method "miRl...

MicroRNAs (miRNAs) are ∼22 nucleotide small noncoding RNA that base-pair with mRNA primarily at the 3′ untranslated region (UTR) to cause mRNA degradation or translational repression [1]. Aberrant miRNA expression is implicated in tumorigenesis [4]. Construction of microRNA regulatory modules (MiRM) will aid deciphering aberrant transcriptional regulatory network in cancer but is computationall...

MicroRNA (miRNA) is an endogenous non-protein coding small RNA molecule that negatively regulates gene expression by the degradation of messenger RNA (mRNA) or the suppression of mRNA translation. miRNA plays important roles in physiologic processes such as cellular development, differentiation, proliferation, apoptosis, and stem cell self-renewal. Studies show that deregulation of miRNA expres...

Abstract Background Competitive endogenous RNA (ceRNA) networks have revealed a new mechanism of interaction between RNAs, and play crucial roles in multiple biological processes development neoplasms. They might serve as diagnostic prognosis markers well therapeutic targets. Methods In this work, we identified differentially expressed mRNAs (DEGs), lncRNAs (DELs) miRNAs (DEMs) sarcomas by comp...

Expression levels of mRNA is regulated by different processes, comprising inhibition or activation by transcription factors (TF) and post-transcriptional degradation by microRNAs (miRNA). biRte (Bayesian Inference of Regulatory influence on Expression (biRte)) uses the regulatory networks of TFs and miRNAs together with mRNA and miRNA expression data to infer the influence of regulators on mRNA...