BACKGROUND Persistent hypotony is a severe complication following trabeculectomy with intraoperative application of mitomycin. OBJECTIVE To reduce this rate of hypotony by using a lower concentration of mitomycin and applying the mitomycin only topically to the filtering bleb following surgery. METHODS Patients were enrolled on a consecutive basis and prospectively followed up. Standard tra...

AIMS To evaluate the long term results of intraoperative mitomycin C application in dacryocystorhinostomy (DCR) surgery compared with results of the conventional procedure. METHODS In this prospective randomised controlled study, a total of 88 eyes diagnosed with acquired nasolacrimal duct obstruction were randomly divided into a conventional DCR group and a mitomycin C group in which mitomyc...

PURPOSE To investigate whether mitochondrial dysfunction and mitogen-activated protein kinase family proteins are implicated in apoptotic signaling of human Tenon's capsule fibroblasts (HTCFs) by mitomycin-C. METHODS Apoptosis was determined by Hoechst nuclei staining, agarose gel electrophoresis, and flow cytometry in HTCFs treated with 0.4 mg/mL mitomycin-C for 5 minutes. Enzymatic digestio...

Mouse L-cells were grown in suspension culture and exposed to varying concentrations, from 0.2 to 4 ¿ig/ml,of mitomycin C for periods ranging from 0.5 to 3.5 hr. A plot of cell colony-forming ability versus concentration of mitomycin C for different times of exposure yielded a series of exponential survival curves which were related by the fact that the product of the time of exposure and the ...

OBJECTIVE To create and test a slow-release antifibrotic drug-coated glaucoma drainage device using in vitro and in vivo experiments. METHODS A slow-release device incorporating mitomycin C in poly(2-hydroxyethyl methacrylate) disks was developed using redox-polymerization techniques. A standardized preparation of this drug delivery device was attached to the Ahmed glaucoma valve (model FP7; ...

OBJECTIVES Mitomycin C, a widely used chemotherapeutic drug, has been proposed as a potential adjuvant for the control of scar tissue in surgical wounds because of its capacity to inhibit fibroblast proliferation. The current study used a combination of topical and injected mitomycin C to slow the healing process of surgical wounds in rats. METHODS An experimental model of surgical wounding a...

Mitomycin C has played a deciding role in the current revival of excimer laser surface ablation techniques. We review the literature regarding mechanism of action of mitomycin C, histological effects on the cornea, and indications, dose, exposure time, and toxicity of mitomycin C in corneal refractive surgery. Mitomycin C is an alkylating agent with cytotoxic and antiproliferative effects that ...

PURPOSE To report a case of primary acquired melanosis (PAM) successfully treated with combined topical mitomycin C and interferon-α2b. CASE REPORT A 75-year-old man presented with an extensive unilateral pigmented lesion involving 360° of the bulbar conjunctiva, extending to the fornices and palpebral conjunctiva. Map biopsy confirmed PAM with local atypia. Treatment was initiated with mitom...

This study aims to provide information about the effect of Mitomycin C on contracted sockets surgery so that can inhibit migration fibroblast and synthesis collagen thus causing reduce fibrosis in vitro vivo a significant reduction scarring. The literature used is last 10 years 2021. Literature searches were from Science Direct, PubMed, Google Scholar electronic databases. initial stage obtaine...

Six of ten bacteriocinogenic strains of Clostridium perfringens were inducible by treating the cultures with mitomycin C. Induction did not occur in the continued presence of mitomycin C but only when excess mitomycin C was removed. Cell death was associated with induction of bacteriocin.