this paper presents a discrete-time single-server finite buffer n threshold policy queue with renewal input and discretemarkovian service process. the server terminates service whenever the system becomes empty, and recommencesservice as soon as the number of waiting customers in the queue is n. we obtain the system-length distributionsat pre-arrival and arbitrary epochs using the supplementary...

The genome of MM1 (40,248 bp), a temperate bacteriophage from the Spain(23F)-1 multiresistant epidemic clone of Streptococcus pneumoniae, is organized in 53 open reading frames (ORFs) and in at least five functional clusters. Bioinformatic and N-terminal amino acid sequence analyses enabled the assignment of possible functions to 26 ORFs. Analyses comparing the MM1 genome with those of other ba...

Abstract In recent years, dramatic outbursts have been identified toward massive protostars via infrared and millimeter dust continuum molecular maser emission. The longest lived outburst (>6 yr) persists in NGC 6334 I-MM1, a deeply embedded object with no near-IR counterpart. Using FORCAST HAWC+ on SOFIA, we obtained the first mid-IR images of this field since began. Despite being undetecte...

active queue management (aqm) plays an important role in the internet congestion control. it tries to enhance congestion control, and to achieve tradeoff between bottleneck utilization and delay. random early detection (red) is the most popular active queue management algorithm that has been implemented in the in internet routers and is trying to supply low delay and low packet loss. red algori...

We have examined the expression of vimentin during the differentiation of mouse myeloid leukemia cells (M1), which were induced to differentiate into macrophages by exposure to conditioned medium (CM) obtained from rat embryo fibroblasts. The synthesis of vimentin, which was examined by two-dimensional gel electrophoresis, increased after 12-24 h of incubation of M1 cells in CM and the elevated...

Context. Star formation efficiency (SFE) theories are currently based on statistical distributions of turbulent cloud structures and a simple model of star formation from cores. They remain poorly tested, especially at the highest densities. Aims. We investigate the effects of gas density on the SFE through measurements of the core formation efficiency (CFE). With a total mass of ∼2 × 104 M , t...

The Edmonston vaccine strain of measles virus (MV-Edm) propagates efficiently in a broad range of human tumor cells, killing them selectively. However, the oncolytic potency of MV-Edm in different human tumor xenograft therapy models is highly variable and there is no convenient way to map the distribution of virus-infected tissues in vivo. To enhance the oncolytic potency of MV-Edm against rad...

Adhesion of tumor cells to host cell layers and subsequent migration are pivotal steps in cancer invasion and metastasis. The small GTP-binding protein RhoA controls cell adhesion and motility through organization of the actin cytoskeleton and regulation of actomyosin contractility. Cultured rat MM1 hepatoma cells migrate through a mesothelial cell monolayer in vitro in a serum-dependent, RhoA-...

The Heidenhain variant defines a peculiar clinical presentation of sporadic Creutzfeldt-Jakob disease (sCJD) characterized by isolated visual disturbances at disease onset and reflecting the early targeting of prions to the occipital cortex. Molecular and histopathological typing, thus far performed in 23 cases, has linked the Heidenhain variant to the MM1 sCJD type. To contribute a comprehensi...

BACKGROUND Ki67 labeling index (Ki67 LI), the percentage Ki67 immunoreactive cells, is a measure of tumor proliferation, with important clinical relevance in breast cancer, and it is extremely important to standardize its evaluation. AIM To test the efficacy of computer assisted image analysis (CAIA) applied to completely digitized slides and to assess its feasibility in routine practice and ...