[structure] A catalytic asymmetric reaction process was designed involving the use of solid-phase reagents and catalysts that constitute the packing of a series of "reaction columns". This process was applied to the catalytic asymmetric synthesis of beta-lactams, yielding pure product after crystallization with exceptional enantio- and diastereoselectivity.

This contribution aims to present a methodology to model and simulate the reactive dividing wall column (RDWC) using commercial software. Feasibility of separation scheme was established with ASPEN DISTILTM. Simulation of flowsheet configuration was performed with ASPEN HYSYSTM, using the two columns model. The reactive zone hosted by the prefractionator was modelled and simulated as backward f...

The hydraulic performance of structured packed columns is characterised by parameters such as loading point, flooding point, dry and wet pressure-drop. These parameters can be positively influenced by optimising the transition areas between two adjacent packing layers. Tests have been done in a two-phase test rig with a rectangular column made of perspex. The test medium is a liquid hydrocarbon...

Corrugated structured packings feature strong preferential flow directions due to their structure of crossing triangular channels. This leads to good radial spreading but makes modelling a challenge. Detailed CFD calculations reflecting the exact packing structure are only feasible for small sections of packing. However, effects like large scale maldistribution and instabilities in the flow fie...

We report a catalytic asymmetric reaction process that involves the use of solid-phase reagents and catalysts that constitute the packing of a series of "reaction columns". This process was applied to the catalytic asymmetric synthesis of beta-lactams, to yield pure products with excellent enantio- and diastereoselectivity. We have identified several advantages to conducting chemical reactions ...