introduction: image quality and accuracy of in vivo activity quantification in spect are affected by collimator penetration and scatter components, especially in high energy imaging. these phenomena highly depend on the collimator characteristic and photon energy. the presence of penetrated and scattered photons from collimator in spect images degrades spatial resolution, contrast and image qua...

Ocular melanoma (OM) is a rare noncutaneous malignancy and consists of 2 different subtypes based on the anatomic location in eye: uveal conjunctival melanoma. Like cutaneous melanoma, OM benefits from nuclear medicine molecular imaging nodal staging clinical management. Through illustration distinctive cases, we aim to demonstrate complementary roles standard lymphoscintigraphy, advanced SPECT...

UNLABELLED A major advance in biomedical science and diagnosis was accomplished with the development of in vivo techniques to image radiolabeled molecules, but limited spatial resolution has slowed down applications to small experimental animals. Here, we present a SPECT system (U-SPECT-I) dedicated to radionuclide imaging of murine organs at a submillimeter resolution. METHODS The high perfo...

The recent introduction of high-resolution molecular imaging technology is considered by many experts as a major breakthrough that will potentially lead to a revolutionary paradigm shift in health care and revolutionize clinical practice. This paper intends to balance the capabilities of the two major molecular imaging modalities used in nuclear medicine, namely positron emission tomography (PE...

Tomographic imaging has revolutionized the medical domain over the last 50 years. Imaging modalities like CT, PET or SPECT have enabled non–invasive diagnosis, patient–specific modeling as well as more accurate treatment, and are increasingly establishing themselves also for interventional use. The theoretical basis for tomographic imaging has been developing over the last century as well, with...

Hybrid imaging techniques provide enhanced visualization of biological targets by synergistically combining multiple imaging modalities, thereby providing information on specific aspects of structure and function, which is difficult to obtain by a single imaging modality. Advances in the field of hybrid imaging have resulted in the recent approval of PET/magnetic resonance (MR) imaging by the U...

Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [111In]-Liposome as a drug delivery vehicle, encapsulating a novel 18F-labeled carboplatin drug derivative ([18F]-FCP) as a dual-molecular imaging tool as bot...