Westudy certain classical basicmodels for bioreactor simulation in case of batchmodewith decay. It is shown that in many cases the two-dimensional differential system describing the dynamics of the substrate and biomass concentrations can be reduced to an algebraic equation for the biomass together with a single differential equation for the substrate. Then from an analogy with the Henri–Michae...

In 1959, Jacques Monod wrote a manuscript entitled Cybernétique enzymatique [Enzymatic cybernetics]. Never published, this unpublished manuscript presents a synthesis of how Monod interpreted enzymatic adaptation just before the publication of the famous papers of the 1960s on the operon. In addition, Monod offers an example of a philosophy of biology immersed in scientific investigation. Monod...

this paper investigates the importance of considering biomass growth and decay for predicting a field scale microbial degradation of btex plume in an unconfined aquifer system in the pump station area of tehran oil refinery (tor), iran. a two-dimensional finite volume model has been presented to predict multi-species reactive transport incorporating physical, chemical and biological processes i...

In response to a 100-word footnote in the 1965 article by Monod, Wyman, and Changeux, a detailed manuscript signed by Francis Crick and Jeffries Wyman with 6000 words and 30 equations entitled "A Footnote on Allostery" circulated in 1965 among a limited group of scientists interested in allosteric interactions. This interesting and provocative document is published in this special issue for the...

As an introduction to my topic, let me quote from the 1970 bestseller, Chance and Necessity, by the late Jacques Monod. In this “essay on the natural philosophy of modern biology”, as the book is subtitled, the celebrated French biologist attempted, as many have done before and after him, to derive some sort of Weltanschauung from the science of his day. On the existence of intelligent life on ...

MOTIVATION Realistic simulation of the kinetic properties of metabolic pathways requires rate equations to be expressed in reversible form, because substrate and product elasticities are drastically different in reversible and irreversible reactions. This presents no special problem for reactions that follow reversible Michaelis-Menten kinetics, but for enzymes showing cooperative kinetics the ...

Jacques Monod, born 100 years ago, was one of the main founders of molecular biology. A quotation of Roger Stanier seems to me of immediate relevance to the topic of this meeting on ‘‘Chance and necessity in evolution,’’ dedicated to the works of Jacques Monod: ‘‘Jacques Monod, one of the great scientists of the twentieth century, will always have an honored place among the leaders of the secon...

The global asymptotic behavior of solutions of the variable yield model is determined. The model generalizes the classical Monod model and it assumes that the yield is an increasing function of the nutrient concentration. In contrast to the Monod model, it is demonstrated that the variable yield model exhibits sustained oscillations. Moreover, it is shown that the variable yield model may under...

Lactiplantibacillus plantarum is a Gram-positive bacterium that belongs to the lactic acid bacteria (LAB) group commonly used in food industry. To use this microorganism, high biomass concentration necessary, and models need be established for predicting improving its behavior along fermentation. However, current L. are applicable only one substrate. The growth of newly isolated strain 60-1 co-...