نتایج جستجو برای: montanide
تعداد نتایج: 327 فیلتر نتایج به سال:
Background: Plasmodium falciparum Apical Membrane Antigen 1 (PfAMAI) is a candidate vaccine antigen expressed by merozoites and sporozoites. It plays a key role in red blood cell and hepatocyte invasion that can be blocked by antibodies. Methodology/Principal Findings: We assessed the safety and immunogenicity of recombinant PfAMAI in a doseescalating, phase la trial. PfAMAI FVO strain, produce...
Introduction MontanideTM ISA 51 VG and MontanideTM ISA 720 VG are adjuvants dedicated to human therapeutic vaccines. The adjuvants are rendering stable water-in-oil (W/O) emulsions when mixed with water phase. In these formulations the active ingredients are entrapped in droplets of water surrounded by continuous oil phase. It allows a protection against degradation and slow release of the acti...
BACKGROUND The P. falciparum chimeric protein 2.9 (PfCP-2.9) consisting of the sequences of MSP1-19 and AMA-1 (III) is a malaria vaccine candidate that was found to induce inhibitory antibodies in rabbits and monkeys. This was a phase I randomized, single-blind, placebo-controlled, dose-escalation study to evaluate the safety and immunogenicity of the PfCP-2.9 formulated with a novel adjuvant M...
Purpose: To investigate targeting of indoleamine 2,3 dioxygenase (IDO) enzyme using a synthetic peptide vaccine administered to patients with metastatic non–small cell lung cancer (NSCLC). Experimental Design: In a clinical phase I study, we treated 15HLA-A2–positive patients with stage III– IV NSCLC in disease stabilization after standard chemotherapy. Patients were treated with imiquimod oint...
Control of Johne's disease, caused by Mycobacterium avium subspecies paratuberculosis (MAP) in ruminants using commercially available vaccine reduces production losses, mortality, fecal shedding and histopathological lesions but does not provide complete protection from infection and interferes with serological diagnosis of Johne's disease and bovine tuberculosis. At this time no recombinant an...
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