Our previous studies had reported that morin, a bioflavanoid exhibited potent anti-inflammatory effect against adjuvant-induced arthritic rats. In this current study, we investigated the anti-inflammatory mechanism of morin against monosodium urate crystal (MSU)-induced inflammation in RAW 264.7 macrophage cells, an in vitro model for acute gouty arthritis. For comparison purpose, colchicine wa...

Various naturally occurring flavonoids have been found to be cancer-protective in chemically induced animal cancer models and synthetic flavonoid derivatives are being tested for potential chemotherapeutic usefulness in clinical trials. This report demonstrates that human oral squamous carcinoma cells (SCC) are significantly more sensitive to growth inhibition by the naturally occurring flavono...

In our previous studies, bacteriostatic action of flavonoids against Staphylococcus aureus ATCC 25 923 and Escherichia coli ATCC 25 922 was demostrated. In the present work synergism of their combinations in order to improve the bacteriostatic action against the same microorganisms was determined. The experiences were made in nutritive broth, maintaining constant one drug concentration (20 micr...

Pancreatic β cells are sensitive to oxidative stress, which is one of the predominant causes of cell damage and the emergence of diabetes. The identification of effective therapeutic strategies to protect pancreatic cells from oxidative stress has increased interest in the screening of antioxidants from natural products. The present study aimed to investigate the protective effects of morin aga...

BACKGROUND Cyclophosphamide (CPX) has many adverse effects, partly due to oxidative stress induction in various tissues. Morin is one of the natural flavonoids with strong antioxidant properties. OBJECTIVES The aim of the current research was to estimate the influence of morin on changes in antioxidant parameters in rat livers after cyclophosphamide administration. MATERIAL AND METHODS The ...

High fructose (HF) feeding induces a moderate increase in blood pressure in rats, which is associated with insulin resistance, hyperinsulinemia, and hypertriglyceridemia. In the present study, we examined the chronic effect of morin, a flavonoid isolated from medicinal plants, on blood pressure, lipid profiles, and serum insulin and glucose in HF-induced hypertensive rats. Rats were divided int...

We prove that the homotopy class of a Morin mapping f : P p → Q with p − q odd contains a cusp mapping. This affirmatively solves a strengthened version of the Chess conjecture [5],[3]. Also, in view of the Saeki-Sakuma theorem [10] on the Hopf invariant one problem and Morin mappings, this implies that a manifold P p with odd Euler characteristic does not admit Morin mappings into R for p ≥ 2k...

We aimed to investigate the effect of morin hydrate on neural stem cells (NSCs) isolated from mouse inner ear and its potential in protecting neuronal hearing loss. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) and bromodeoxyuridine incorporation assays were employed to assess the effect of morin hydrate on the viability and proliferation of in vitro NSC culture. The N...

Received 06 July 2012, Revised 15 December 2012, Accepted 16 December 2012 -------------------------------------------------------------------------------------------------------------------------------------------Abstract The study focuses on the interaction between morin and Tin(II) and the resulting complex was characterized through various analytical techniques by comparing it with morin. T...

The potential role of morin in the treatment of diabetes along with its antihyperlipedemic effects was studied in streptozotocin-induced diabetic rats. Diabetes was induced in male Wister rats by single intraperitoneal injection (i.p) of 50 mg/kg streptozotocin. Morin was administered orally at doses of 50 and 100 mg/kg for 45 days. At the end of this experiment the effect of morin on plasma gl...