AIM Resveratrol is a popular ingredient in dietary supplements. Some patients concomitantly use dietary supplements and medicines in Japan. In the present study, we determined whether trans-resveratrol and melinjo (Gnetum gnemon L.) seed extract (MSE), which contains resveratrol dimers, interacted with drugs using a mouse model. METHODS Male C57BL/6J mice were fed experimental diets containin...

Background Previous work suggests that major depressive disorder (MDD) is associated with disturbances in global connectivity among brain regions, as well as local connectivity within regions. However, the relative importance of these global versus local changes for successful antidepressant treatment is unknown. We used multiscale entropy (MSE), a measure of brain signal variability, to examin...

Breast cancer is the leading cause of new cancer diagnoses among women. Using peroxisome proliferator-activated receptor (PPAR)γ((+/-)) mice, we showed normal expression of PPARγ was critical to stop 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast tumorigenesis. PPARγ is expressed in many breast cell types including mammary secretory epithelial (MSE) cells. MSEs proliferate as required dur...

Considering a heterogeneous network (HetNet) system consisting of a macro tier overlaid with a second tier of small cells (SCs), this paper studies the mean square error (MSE) based precoding design to be employed by the macro base station and the SC nodes for multiple-input multipleoutput (MIMO) downlinks. First, a new sum-MSE of all users based minimization problem is proposed aiming to desig...

Melinjo (Gnetum gnemon L.) seed extract (MSE) containing trans-resveratrol (3,5,4'-trihydroxy-trans-stilbene) and other derivatives exerts various beneficial effects. However, its mechanism of action in humans remains unknown. In this study, we aimed to investigate beneficial effects of MSE in healthy adult males. In this double-blind, randomized controlled study, 30 males aged 35-70 years with...

Abstruct-Rate of convergence results are established for vector quantization. Convergence rates are given for an increasing vector dimension and/or an increasing training set size. In particular, the following results are shown for memoryless realvalued sources with bounded support at transmission rate R: (1) If a vector quantizer with fixed dimension k is designed to minimize the empirical mea...

Aims and method To investigate medical students' performance at and perceptions of the mental state examination (MSE) at a medical school with a modern integrated curriculum. We undertook an evaluative case study comprising a survey and analysis of performance data. The study is presented in two parts: part 1 discusses the students' perceptions of the MSE and the teaching, learning and practisi...

In this paper, a relationship between Linear Discriminant Analysis (LDA) and the generalized Minimum Squared Error (MSE) solution is presented. The generalized MSE solution is shown to be equivalent to applying a certain classification rule in the space defined by LDA. The relationship between the MSE solution and Fisher Discriminant Analysis (FDA) is extended to multi-class problems and also t...

Objectives: (1) To understand what hardness is, and how it can be used to determine material properties. (2) To conduct typical engineering hardness tests and be able to recognize commonly used hardness scales and numbers. (3) To be able to understand the correlation between hardness numbers and the properties of materials (4) To learn the advantages and limitations of the common hardness test ...