BACKGROUND There is need for a cognitive test battery that can be easily used in clinical practice to detect or monitor cognitive performance in patients with multiple sclerosis (MS). In order to conduct, in this patient group, a preliminary investigation of the validity and utility of a brief computerized battery, the Cognitive Drug Research (CDR) battery, we longitudinally assessed cognition ...

Mittlefehldt, R. Gellert, K. E. Herkenhoff, R. V. Morris, B. C. Clark, B. A. Cohen, I. Fleischer, B. L. Jolliff, G. Klingelhöfer, D. W. Ming, R. A. Yingst and the Athena Science Team, NASA/JSC, Houston, TX USA ([email protected] ), Univ. Guelph, Guelph, ON CA, USGS, Flagstaff, AZ USA, SSI, Boulder, CO USA, NASA/MSFC, Huntsville, AL USA, Johannes Gutenberg-Univ., Mainz, DE, Washingto...

Space vehicle loads and trajectory assessments utilize archives of both discrete and sequential wind profiles to ensure robust structural integrity during vehicle design. Historically, vehicle programs have used balloonbased measurements, which have three primary limitations inherent to balloon systems. First, the high cost of balloon releases makes high-frequency balloon sampling impractical, ...

Space vehicle loads and trajectory assessments utilize archives of both discrete and sequential wind profiles to ensure robust structural integrity during vehicle design. Historically, vehicle programs have used balloonbased measurements, which have three primary limitations inherent to balloon systems. First, the high cost of balloon releases makes high-frequency balloon sampling impractical, ...

BACKGROUND Treatment options for patients suffering from progressive forms of multiple sclerosis (MS) remain inadequate. Mast cells actively participate in the pathogenesis of MS, in part because they release large amounts of various mediators that sustain the inflammatory network. Masitinib, a selective oral tyrosine kinase inhibitor, effectively inhibits the survival, migration and activity o...

OBJECTIVE There is increasing evidence that altered glutamate (Glu) homeostasis is involved in the pathophysiology of multiple sclerosis (MS). The aim of this study was to evaluate the in vivo effects of excess brain Glu on neuroaxonal integrity measured by N-acetylaspartate (NAA), brain volume, and clinical outcomes in a large, prospectively followed cohort of MS subjects. METHODS We used mu...

BACKGROUND Interferon beta-1a (IFNbeta-1a, Avonex) is efficacious in relapsing forms of MS. Studies of other IFNbeta preparations in secondary progressive MS (SPMS) yielded conflicting results. This study was undertaken to determine whether IFNbeta-1a slowed disease progression in SP-MS. METHODS A total of 436 subjects with SPMS and Expanded Disability Status Scale (EDSS) score 3.5 to 6.5 wer...

One possible explanation for this result is the size of the standard deviations of the measurements, which might be related to the wide range of Expanded Disability Status Scale (EDSS) scores permitted for patient inclusion. We are aware that a smaller range of EDSS scores would have selected a more homogeneous sample of subjects and probably would have reduced the size of the standard deviatio...