Mesoporous silica nanoparticles (MSNs) have been synthesized and loaded with both aluminum chloride phthalocyanine (AlClPc) and cisplatin as combinatorial therapeutics for treating cancer. The structural and photophysical properties of the MSN materials were characterized by different spectroscopic and microscopic techniques. Intracellular uptake and cytotoxicity were evaluated in human cervica...

Multidrug resistance (MDR) is the major clinical obstacle in the management of cancer by chemotherapy. Overexpression of ATP-dependent efflux transporter P-glycoprotein (PGP) is a key factor contributing to multidrug resistance of cancer cells. The purpose of the present study was to use the endosomal pH-sensitive MSN (mesoporous silica nanoparticles; MSN-Hydrazone-Dox) for controlled release o...

Medium spiny neurons (MSNs) are the major striatal neuron and receive synaptic input from both glutamatergic and dopaminergic afferents. These synapses are made on MSN dendritic spines, which undergo density and morphology changes in association with numerous disease and experience-dependent states. Despite wide interest in the structure and function of mature MSNs, relatively little is known a...

The Manhattan Street Network (MSN) is a digraph resulting from labeling the edges of a torus with directions. We study some of the basic properties of the MSN labeling. We prove a lower bound on the stretch of any path due to such a labeling, and that the maximum stretch of the MSN meets this bound. We also prove that the diameter of the MSN is not optimal as there exists another labeling of th...

Practice Guideline for the Promotion of Perioperative Normothermia Vallire D. Hooper, PhD, RN, CPAN, FAAN, Robin Chard, PhD, RN, CNOR, Theresa Clifford, MSN, RN, CPAN, Susan Fetzer, PhD, RN, Susan Fossum, BSN, RN, CPAN, Barbara Godden, MHS, RN, CPAN, CAPA, Elizabeth A. Martinez, MD, MHS, Kim A. Noble, PhD, RN, CPAN, Denise O’Brien, MSN, RN, ACNS-BC, CPAN, CAPA, FAAN, Jan Odom-Forren, PhD, RN, C...

Striatal medium spiny neurons (MSN) are critically involved in motor control, and their degeneration is a principal component of Huntington's disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is central to MSN differentiation and striatal development. Within the striatum, it is expressed by all MSN, although it is excluded from essentially all striatal interneurons. In...

Non- and semipolar GaN have great potential to improve the efficiency of light emitting devices due to much reduced internal electric fields. However, heteroepitaxial GaN growth in these crystal orientations suffers from very high dislocation and stacking faults densities. Here, we report a facile method to obtain low defect density non- and semipolar heteroepitaxial GaN via selective area epit...

Misshapen (Msn) has been proposed to shut down Drosophila photoreceptor (R cell) growth cone motility in response to targeting signals linked by the SH2/SH3 adaptor protein Dock. Here, we show that Bifocal (Bif), a putative cytoskeletal regulator, is a component of the Msn pathway for regulating R cell growth cone targeting. bif displays strong genetic interaction with msn. Phenotypic analysis ...

Recent advancements in the synthesis of monodispersed, large average pore diameter mesoporous silica nanoparticle (MSN) materials with highly functionalizable surface area ( ≥ 400 m 2 g − 1 ) and pore volume (1.05 cm 3 g − 1 ) has led to the development of a series of biomolecule delivery vehicles, where various proteins, small DNA and RNA sequences, and other biomolecules are loaded into the m...

A microsphere composite made of poly(DL-lactic-co-glycolic acid) (PLGA), mesoporous silica nanoparticle (MSN), and nanohydroxyapatite (nHA) (PLGA-MSN/nHA) was prepared and evaluated as bone tissue engineering materials. The objective of this study was to investigate the synergistic effect of MSN/nHA on biocompatibility as well as its potential ability for bone formation. First, we found that th...