Mammalian target of rapamycin (mTOR) has an important role in various biological processes in cells. In the present study, we investigated temporal changes in mTOR and phosphorylated-mTOR (p-mTOR) expressions in the rat hippocampal CA1 region following chronic cerebral hypoperfusion (CCH) induced by permanent bilateral common carotid arteries occlusion (2VO). The mTOR immunoreactivity in the py...

The maintenance of skeletal muscle mass contributes substantially to health and to issues associated with the quality of life. It has been well recognized that skeletal muscle mass is regulated by mechanically induced changes in protein synthesis, and that signaling by mTOR is necessary for an increase in protein synthesis and the hypertrophy that occurs in response to increased mechanical load...

Background Akt and mechanistic target of rapamycin (mTOR) signaling pathways are implicated in AD pathology. Activation these by external cues facilitates new protein synthesis at the synapse which leads to synaptic plasticity. We have demonstrated that activity dependent Akt1 mediated is abolished primary cortical neurons APP/PS1 mice. However, molecular underpinnings for impairment still elus...

mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth. We report that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two roles in the mTOR pathway. Raptor has a positive role in nutrient-stimulated signaling to the downst...

This study aims to explore the cytotoxic, apoptotic and autophagic effects of thymoquinone on human acute myeloid leukemia. The cytotoxic were determined with 3-(4, 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide (MTT) tests. B-cell lymphoma 2 associated X protein (Bax), (Bcl-2), caspase 3, mammalian target rapamycin (mTOR), phosphatidylinositol-3-kinase (PI3K), kinase B (AKT) gene expr...

Macrophages can change their phenotypes according to the changes in microenvironment, and thus have various functions, that is, macrophages polarization. Macrophage phenotype is associated with progression of atherosclerotic plaques. Studies shown a large accumulation p62 protein Whether affects level macrophage polarization inflammation its mechanism not clear. The levels treated ox-LDL were d...

This study discusses the construction of mathematical models for mechanism protein synthesis involving main regulator mTORC1 gene which is described in singular pathway mTOR AMPK pathway. The genes question include: AMPK, TSC2, Rheb, and S6K. method used this research divided into two stages, namely analysis second formulation models. Pathway performed as a reference describing interactions for...

................................................................................................................3 Introduction............................................................................................................3 1 TOR /mTOR and its associated protein..........................................................................5 1.1 TOR and its associated protein in yeast.......

UNLABELLED Mammalian target of rapamycin (mTOR) is a key regulator of cell growth, proliferation and angiogenesis. mTOR signaling is frequently hyper activated in a broad spectrum of human cancers thereby making it a potential drug target. The current drugs available have been successful in inhibiting the mTOR signaling, nevertheless, show low oral bioavailability and suboptimal solubility. Con...

Inflammatory processes have been shown to be involved in development and progression of neurodegenerative diseases. Mammalian target of rapamycin (mTOR) involves in various cellular processes including autophagy, apoptosis and energy metabolism. Recently, studies have been shown an association between mTOR pathway and inflammation, supporting the role of the pathway in the pathogenesis of infla...