Patients with pancreatic adenocarcinoma are known to have a high mortality rate. The 5-year survival rate still remains low even now compared to that of the 1960's despite new advances in management including surgery, chemotherapy, pathological classification and molecular diagnostic technologies. Precursors to invasive pancreatic adenocarcinoma have been identified in the last ten years that i...

The PathfinderTG biomarker panel is useful in the evaluation of pancreatic cysts that have clinical features suspicious for malignancy, but its utility in classifying fine-needle aspiration biopsies from small pancreatic cystic lesions is yet to be proven. We used morphology to classify 20 pancreatic cyst cytology aspirates, all of which met radiographic criteria for close observation. Cases we...

This case was an old woman who had been suffering from peripancreatic space occupying lesions for more than 3 years. She underwent distal pancreatectomy and splenectomy. Under a microscopic examination, the tumor was composed of well-differentiated mucinous cystic neoplasm (MCN) and poorly differentiated anaplastic giant-cell carcinoma. Tumor giant-cells engulfing the neutrophils were visible i...

Non-inflammatory cystic lesions of the pancreas are increasingly recognized. Two distinct entities have been defined, i.e., intraductal papillary mucinous neoplasm (IPMN) and mucinous cystic neoplasm (MCN). Ovarian-type stroma has been proposed as a requisite to distinguish MCN from IPMN. Some other distinct features to characterize IPMN and MCN have been identified, but there remain ambiguitie...

pected to be a mucinous cystic adenocarcinoma. We performed en bloc distal pancreatectomy and splenectomy. The macroscopic appearance was consistent with mucinous cystic neoplasm ( fig. 3 ). Microscopy showed epithelium composed of mucin-secreting cells and a dense cellular ovarian-type stroma ( fig. 4 ). Adenocarcinoma was A 41-year-old woman was referred to our hospital for evaluation of an a...

CONTEXT An intraductal oncocytic papillary neoplasm is a rare pancreatic tumor which was first described by Adsay et al. in 1996. It has been defined as a new subgroup of IPMN. CASE REPORT We report the case of a 76-year-old woman who presented with nausea. Imaging studies revealed a cystic mass in the body of the pancreas. She underwent a successful distal pancreatectomy and splenectomy, and...

BACKGROUND Mucinous cystadenocarcinoma is the second most common etiology of appendiceal mucocele. We report a relatively rare case of a giant appendiceal mucocele caused by mucinous cystadenocarcinoma, which occupied the entire abdomen of an adult woman. CASE PRESENTATION A 63-year-old woman presented with a chief complaint of abdominal distention. Imaging studies showed a giant cystic mass ...

BACKGROUND AND STUDY AIMS Endoscopic ultrasound (EUS) surveillance of patients with mucinous pancreatic cysts relies on the assessment of morphologic features suggestive of malignant transformation. These criteria were derived from the evaluation of surgical pathology in patients with pancreatic cysts who underwent surgery. Reliability of these criteria when evaluated by EUS in identifying lesi...

OBJECTIVE The objectives of this analysis were to define the incidence, natural history, and predictors of neoplasia in pancreatic cysts to determine which patients can safely be observed and which should undergo an operation. SUMMARY BACKGROUND DATA With advancements in imaging technology, cystic lesions of the pancreas are being detected with increased frequency. Many of these lesions are s...

BACKGROUND Although intraductal papillary mucinous neoplasm (IPMN) of the pancreas is acceptable as a distinct disease entity, the concept of mucin-secreting biliary tumors has not been fully established. CASE PRESENTATION We describe herein a case of mucin secreting biliary neoplasm. Imaging revealed a cystic lesion 2 cm in diameter at the left lateral segment of the liver. Duodenal endoscop...