Background: Angiokeratoma is an asymptomatic, hyperkeratotic, capillary disorder of the skin present as solitary or multiple, keratotic papules or plaques, which may also be related to Fabry disease. Oral involvement may be observed in cases of widespread muco-cutaneous angiokeratomas, whereas solitary buccal angiokeratoma without systemic/ cutaneous involvement is extremely rare. Case Report: ...

Paraneoplastic pemphigus (PNP) also called Autoimmune Multiorgan Syndrome (PAMS), is a rare but severe clinical variant of with high mortality rate. It clinically characterized by polymorphic muco-cutaneous and polyorgan involvement in association malignancies mostly lymphoproliferative origin. The diagnosis PNP/PAMS requires specific clinical, histological immunological criteria. In Bulgaria t...

Background Recent data show that almost 75% of HIV patients have muco-cutaneous diseases, the proportion of patients with dermatoses being inversely proportional to the CD4 + and directly proportional to the stage of disease. Papulo-pustular eruption is the most common pruritic dermatosis in patients with HIV infection, followed by seborrheic dermatitis, psoriasis, molluscum contagiosum and dru...

BACKGROUND Leishmania braziliensis is the most prevalent species isolated from patients displaying cutaneous and muco-cutaneous leishmaniasis in South America. However, there are difficulties for studying L. braziliensis pathogenesis or response to chemotherapy in vivo due to the natural resistance of most mouse strains to infection with these parasites. The aim of this work was to develop an e...

We report four HCV-HIV-coinfected patients who developed herpes zoster or muco-cutaneous herpes virus disease shortly after starting interferon-free antiviral treatment for HCV. We suggest that in our patients the prompt clearance of HCV following direct-acting antivirals leads to a paradoxical effect on the innate and adaptive immune system mediating the reactivation of herpetic infection.

Herein, a 28-year-old man with hoarseness, skin and oral lesions is presented. At the time of admission, the patient had an erythematous plaque on his chin near his lower lip and an erythematous-violaceous plaque on his palate near the opening of the pharynx and 20 kg weight lost in last one year. The biopsy of his skin lesions by hematoxylin and eosin staining revealed an infiltration of the d...

Rhinosporidiosis is a chronic, granulomatous, muco-cutaneous infection caused by Rhinosporidium seeberi . The non-contagious and sporadic in humans, affecting predominantly the mucous membrane of upper respiratory tract. It quite an uncommon condition seldom affects oral mucosa. clinical presentation this cavity can mimic many other conditions. Here, we report unique case recurrent rhinosporidi...

Coronavirus disease 2019 (COVID-19) is an illness caused by the novel coronavirus designated as severe acute respiratory syndrome 2 (SARS-CoV-2). It was first identified in Wuhan, China, December 2019, and soon spread all over world causing a global pandemic. Since beginning of pandemic, fewer cases COVID-19 have been reported children than adults. Most mild only small proportion infected neede...

PEN also known as ‘solitary circumscribed neuroma’ is an uncommon, sporadic, cutaneous, benign, intraneural tumor, which usually presents as asymptomatic, solitary or multiple, firm, rubbery, skin-coloured or pink, papule or nodule, commonly localized on the face or close to a muco-cutaneous junction in middle aged adults with equal sex preponderance [1]. It was first described by Reed et al in...